Cycloolivil 是一种天然多酚化合物,在橄榄树中具有显着的自由基清除活性。 Cycloolivil 具有抗氧化活性,它可以预防与血小板过度聚集相关的血栓并发症,是开发抗聚集治疗策略的基础。
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Cycloolivil is a natural polyphenolic compound with a significant radical scavenging activity present in olive trees. Cycloolivil has antioxidant activity, it may prevent thrombotic complications associated to platelet hyperaggregability and be the base
体外活性
Cycloolivil reduced the ability of thrombin to stimulate platelet aggregation. Cycloolivil reduced thrombin-evoked Ca(2+) release and entry to a similar extent to hydroxytyrosol. This effect was greater in platelets from patients with type 2 diabetes mellitus than in controls. Thrombin-, thapsigargin- and 2,5-di-(tert-butyl)-1,4-hydroquinone (TBHQ)-evoked protein tyrosine phosphorylation, which is involved in Ca(2+) signalling and platelet aggregation, is inhibited by Cycloolivil. Cycloolivil is a natural oxygen radical scavenger that reduces thrombin-induced protein tyrosine phosphorylation, Ca(2+) signalling and platelet aggregation[1].
Cas No.
3064-05-9
分子式
C20H24O7
分子量
376.4
别名
Isoolivil;环橄榄树脂素
储存和溶解度
(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years