DHQZ 36 is a potent inhibitor of retrograde trafficking. DHQZ 36 inhibitsLeishmaniaamazonensisinfectionin macrophages with anEC₅₀of 13.63 μM. DHQZ 36 has potent anti-parasite activity^[1].

EC50: 13.63 μM (Leishmania amazonensis)^[1]

With increasing concentrations of DHQZ 36 there is a significant diminution in the size of parasitophorous vacuoles (LPVs), vacuole sizes are reduced by 30% at 50 μM. These parasites also cause a reduction in the number of parasites per macrophage. Significant parasite loss is observed with as low as 5 μM after treatment with DHQZ 36. Parasites are unable to recover growth when treated with DHQZ 36 at concentrations at or above 12.5 μM^[1].
DHQZ 36 causes over 40% reduction in secreted of parasite proteins. DHQZ 36 causes a reversal inLeishmaniainduced suppression of IL-6 release by infected cells after LPS activation^[1].

384.44

C₂₁H₁₈F₂N₂OS

1542098-94-1

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