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Gedunin
本半岛bd体育手机客户端 不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Gedunin图片
CAS NO: 2753-30-2
包装: 1mg
市场价: 1498元

半岛bd体育手机客户端 介绍
Gedunin 是一种柠檬苦素,具有抗癌、抗病毒、抗炎和杀虫活性。
Cas No. 2753-30-2
别名 葛杜宁
化学名 (1R,3aS,4aR,4bR,5S,6aS,10aR,10bS,12aS)-1-(furan-3-yl)-4b,7,7,10a,12a-pentamethyl-3,8-dioxo-1,3,3a,4b,5,6,6a,7,8,10a,10b,11,12,12a-tetradecahydronaphtho[2,1-f]oxireno[2,3-d]isochromen-5-yl acetate
Canonical SMILES O=C1O[C@H](C2=COC=C2)[C@@]3(C)[C@]4([C@]5(C)[C@@H](CC3)[C@@](C)(C=C6)[C@@H](C(C)(C)C6=O)C[C@@H]5OC(C)=O)O[C@@H]41
分子式 C28H34O7
分子量 482.57
溶解度 Acetonitrile: 1 mg/ml,DMSO: 100 mM,Ethanol: 1 mg/ml,Methanol: 1 mg/ml
储存条件 Store at -20℃
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
半岛bd体育手机客户端 描述

Gedunin, a naturally occurring Hsp90 inhibitor, is tetranortriterpenoid isolated from the Indian neem tree (Azadirachta indica).

Hsp90 (heat shock protein 90) is a chaperone protein stabilizes proteins against heat stress, and aids in protein degradation. Originally, this protein was isolated by extracting proteins from cells stressed by heating, dehydrating or by other means. It also stabilizes a number of proteins required for tumor growth, thereby Hsp90 inhibitors are investigated as anti-cancer drugs.

In vitro, Gedunin induces degradation of Hsp90-dependent client protein and displays anti-proliferative activity in SKBr3, CaCo-2 and MCF-7 cancer cell lines with IC50 of 3.22, 16.8 and 8.84 μM respectively1.

Gedunin treatment was shown to exhibit anti-malarial activity against P. falciparum in parasite development and [3H]-hypoxanthine uptake assays with IC50 values of 0.14 and 3.1 μM respectively 2. Using mouse model, gedunin was demonstrated to present remarkable anti-inflammatory and anti-nociceptive effects on zymosan-induced inflamed knee joints, modulation of different cell populations3.

References:
1. Uddin SJ, Nahar L, Shilpi JA, et al. Gedunin, a limonoid from Xylocarpus granatum, inhibits the growth of CaCo-2 colon cancer cell line in vitro. Phytotherapy research : PTR. 2007;21(8):757-761.
2. Lee SE, Kim MR, Kim JH, et al. Antimalarial activity of anthothecol derived from Khaya anthotheca (Meliaceae). Phytomedicine : international journal of phytotherapy and phytopharmacology. 2008;15(6-7):533-535.
3. Conte FP, Ferraris FK, Costa TE, et al. Effect of gedunin on acute articular inflammation and hypernociception in mice. Molecules. 2015;20(2):2636-2657.

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