生物活性

GSK 650394是一种糖皮质激素和血清调节激酶1（SGK1）抑制剂，对LNCaP前列腺癌细胞系表现出抗增殖特性。

靶点信息

SGK1	SGK2
62 nM	103 nM

化学数据

目录号	A13309
作用机制	Inhibitor (抑制剂)
M. Wt	382.45
Formula	C25H22N2O2
Purity	>99%
Storage	Store lyophilized at -20?C, keep desiccated. In lyophilized form, the chemical is stable for36 months. In solution, store at -20?C and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	890842-28-1
Synonyms	GSK 650394, GSK650394
SMILES	C1CCC(C1)C2=C(C=CC(=C2)C3=CNC4=NC=C(C=C34)C5=CC=CC=C5)C(=O)O

溶解度

In vitro	DMSO	72 mg/mL (188.25 mM)
	Water	Insoluble
	Ethanol	Insoluble
*<1 mg/ml means slightly soluble or insoluble. *Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	26.15 mL	130.74 mL	261.47 mL
0.5 mM	5.23 mL	26.15 mL	52.29 mL
1 mM	2.61 mL	13.07 mL	26.15 mL
5 mM	0.52 mL	2.61 mL	5.23 mL

*The above data is based on the productmolecular weight 382.45. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.