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STAT3-IN-14
本半岛bd体育手机客户端 不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
STAT3-IN-14图片
CAS NO: 123297-90-5
包装与价格：
包装 价格(元)
100mg 电议
250mg 电议
500mg 电议

半岛bd体育手机客户端 介绍
STAT3-IN-14（Compound 1） 是一种 STAT3抑制剂，具有 STAT3 磷酸化抑制活性，可直接与 STAT3的铰链区结合。
生物活性

STAT3-IN-14 (Compound 1) is aSTAT3inhibitor and hasSTAT3phosphorylation inhibitory activity. STAT3-IN-14 (Compound 1) can directly bind to the hinge region ofSTAT3[1].
IC50& Target

IC50: 0.42 μM (MDA-MB-231); 0.50 μM (MCF7); 0.13 μM (A549)[1]
体外研究
(In Vitro)

STAT3-IN-14 (Compound 1) shows inhibitory activity against phosphor-STAT3.
STAT3-IN-14 (Compound 1) reduces the phosphorylation inhibitory activity against MDA-MB-231 cells (JAK/STAT pathway constitutively active) in does dependent manner, but no inhibitory activities against JAK kinases.
STAT3-IN-14 (Compound 1) has growth inhibitory activity with with IC50values of 0.42 μM, 0.50 μM and 0.13 μM in MDA-MB-231, MCF7 and A549cells, respectively[1].

Western Blot Analysis[1]

Cell Line: MCF7 cells; MDA-MB-231 cells
Concentration: 1 or 10 μM; 0.5, 1, 2, 4 μM
Incubation Time: 1 h; 2 h
Result: Completely inhibited STAT3 phosphorylation at 10 μM, and partial inhibition at 1 μM.
Reduced the phosphorylation of STAT3 in does dependent manner.

Cell Proliferation Assay[1]

Cell Line: MDA-MB-231, MCF7 and A549 cells
Concentration: 0-30 μM
Incubation Time: 72 h
Result: Showed moderate to strong growth inhibitory activity among the three cancer cell lines.
分子量

258.23
Formula

C14H10O5
CAS 号

123297-90-5
结构分类
  • Quinones
  • Naphthalene Quinones
来源
  • Plants
  • Solanaceae
  • Nicotiana tabacumL.
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
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