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L-AP3

本半岛bd体育手机客户端不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

23052-80-4

包装与价格：

半岛bd体育手机客户端名称

3-Phosphono-L-alanine

半岛bd体育手机客户端介绍

L-AP3，代谢型谷氨酸受体 ( mGluR) 拮抗剂，抑制 D-磷酸丝氨酸和 L-磷酸丝氨酸的 IC ₅₀s 分别为 368 μM 和 2087 μM。

生物活性	L-AP3, metabotropic glutamate receptor (mGluR) antagonist, inhibitsD-phosphoserineandL-phosphoserinewithIC₅₀s of 368 μM and 2087 μM, respectively^[1].
体外研究 (In Vitro)	L-AP3 inhibits D-phosphoserine and L-phosphoserine with K_is of 151 μM and 845 μM, respectively^[1]. L-AP3 has agonistic activity in enhancing phospholipase D activity and decreasing CAMP formation in rat hippocampus^[1]. L-AP3 may have selectivity for Group II subtypes since it inhibits [³H]glutamate binding to mGlu3, receptors (K_i125 μM)^[1]. L-AP3 is a potent inhibitor of sodium-dependent L-[³H]glutamate uptake in cerebellar and cortical synaptosomes (39 and 110 μM, respectively)^[1].
体内研究 (In Vivo)	L-AP3 has anticonvulsant activity in animals. L-AP3 blocks audiogenic seizures in DBA/2 mice^[1].
分子量	169.07
Formula	C₃H₈NO₅P
CAS 号	23052-80-4
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.