您好，欢迎来到半岛电竞官方网址 ！ [ 登录] [ 免费注册]
半岛电竞官方网址
发布求购
位置： 首页> 半岛bd体育手机客户端 库> Biperiden lactate
立即咨询
咨询类型：
*姓名：
*电话：
*单位：
Email：
*留言内容：
请详细说明您的需求。
*验证码：
Biperiden lactate
本半岛bd体育手机客户端 不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Biperiden lactate图片
CAS NO: 7085-45-2
包装与价格：
包装 价格(元)
100mg 电议
250mg 电议
500mg 电议

半岛bd体育手机客户端 名称
KL 373 lactate
半岛bd体育手机客户端 介绍
Biperiden (KL 373) lactate 是一种具有口服活性的非选择性毒蕈碱受体 ( muscarinic receptor) 拮抗剂，可以与 M1毒蕈碱受体竞争性结合，从而抑制乙酰胆碱 ( acetylcholine) 并增强中枢神经系统中多巴胺信号传导。 Biperiden (KL 373) lactate 可用于帕金森病以及其他相关精神疾病的研究。
生物活性

Biperiden (KL 373) lactate is an orally active non-selectivemuscarinic receptorantagonist that competitively binds toM1muscarinic receptors. Biperiden (KL 373) lactate inhibitsacetylcholineand enhances dopamine signaling in the central nervous system. Biperiden (KL 373) lactate has the potential for the research of Parkinson's disease and other related psychiatric disorders[1][2].
体外研究
(In Vitro)

Biperiden lactate (29.6 μg/ml, 72 hours) can significantly induce apoptosis and inhibit proliferation at high doses in human pancreatic ductal adenocarcinoma cells[1].

Cell Proliferation Assay[1]

Cell Line: Panc-1, Panc-2 and BxPC3 human pancreatic ductal adenocarcinoma cells
Concentration: 29.6 μg/mL
Incubation Time: 72 hours
Result: Inhibited cell proliferation at 72 hours significantly by reducing nuclear c-Rel translocation.
体内研究
(In Vivo)

Biperiden lactate (intraperitoneal injection, 10 mg/kg, everyday, 3 weeks) reduces tumor size by 83% in subcutaneous xenograft mouse using Panc-1 human pancreatic ductal adenocarcinoma cells[1].
Biperiden lactate (intraperitoneal injection, 8 mg/kg, every 8 hours, 10 days) can reduce frequency of spontaneous seizures and extracellular hippocampal glutamate levels while cause a long-term decrease in hippocampal excitability[2].

Animal Model: Subcutaneous xenograft mouse using Panc-1 human pancreatic ductal adenocarcinoma cells[1]
Dosage: 10 mg/kg
Administration: Intraperitoneal injection; everyday; 3 weeks
Result: Tumor size reduced by 83%.
Animal Model: Male Wistar rats (200-250 g)[2]
Dosage: 8 mg/kg
Administration: Intraperitoneal injection; every 8 hours; 10 days
Result: Reduced late seizures by about three times with no affecting emotional memory damage
Clinical Trial
分子量

401.54
Formula

C24H35NO4
CAS 号

7085-45-2
中文名称

乳酸比哌立登
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Baidu
map