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Dicyclomine
本半岛bd体育手机客户端 不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Dicyclomine图片
CAS NO: 77-19-0
包装与价格：
包装 价格(元)
100mg 电议
250mg 电议
500mg 电议

半岛bd体育手机客户端 名称
Dicycloverine
半岛bd体育手机客户端 介绍
Dicyclomine (Dicycloverine) 是一种有效的口服活性毒蕈碱胆碱能受体 ( muscarinic cholinergic receptors) 拮抗剂。Dicyclomine (Dicycloverine) 对 M1 受体亚型 ( Ki=5.1 nM) 和 M2 受体亚型 ( Ki=54.6 nM) 在刷缘膜和基底质膜中均表现出较高的亲和力。Dicyclomine (Dicycloverine)是一种抗痉挛试剂，在体内可缓解胃肠道平滑肌痉挛。
生物活性

Dicyclomine (Dicycloverine) is a potent and orally activemuscarinic cholinergic receptorsantagonist. Dicyclomine (Dicycloverine) shows high affinity for muscarinic M1 receptor subtype (Ki=5.1 nM) and M2 receptor subtype (Ki=54.6 nM) in brush-border membrane and basal plasma membranes, respectively[1]. Dicyclomine is an antispasmodic agent and relieves smooth muscle spasm of the gastrointestinal tract in vivo[2].
体内研究
(In Vivo)

Dicyclomine (Dicycloverine) (intraperitoneal injection; 8 mg/kg; daily) exacerbates the cognitive impairments in all the measurements. In addition, the memory impairments are worse in dicyclomine-treated 3xTg-AD mice compared to dicyclomine-treated NonTg mice[2].
Dicyclomine (Dicycloverine) (intraperitoneal injection; 2.0, 4.0, and 8.0 mg/kg; 7 days) produces a highly significant effect on performance in the paired-associates learning (PAL) task in mice.And systemic treatment at lower doses show behavioral impairments in mice in spatial tasks[3].

Animal Model: C57Bl/6 mice[1]
Dosage: 2.0, 4.0, and 8.0 mg/kg
Administration: Intraperitoneal injection; daily; 7 days
Result: Produced impairments due to actions of the agent outside of the hippocampus.
分子量

309.49
Formula

C19H35NO2
CAS 号

77-19-0
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
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