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P32/98 hemifumarate
本半岛bd体育手机客户端 不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
P32/98 hemifumarate图片
CAS NO: 251572-86-8
包装与价格：
包装 价格(元)
100mg 电议
250mg 电议
500mg 电议

半岛bd体育手机客户端 名称
异亮氨酸噻唑烷半富马酸盐
半岛bd体育手机客户端 介绍
P32/98 hemifumarate 是一种二肽基肽酶 IV ( DPP4) 抑制剂。P32/98 hemifumarate 在 Zucker 糖尿病大鼠模型中可改善葡萄糖耐量、胰岛素敏感性和 β 细胞反应性。
生物活性

P32/98 hemifumarateis a potent inhibitor ofdipeptidyl peptidaseIVwith a Kivalue of 130 nM. P32/98 hemifumarate improves glucose tolerance,insulinsensitivity and β-cell responsiveness in fatty Zucker rat model[1][2][3].
IC50& Target

DPP-4

130 nM (Ki)
体外研究
(In Vitro)

GLP-1 acts function of stimulation of glucose dependent insulin secretion and induction of satiety feelings, and DPPIV is the major renal catabolic pathway for GLP-1 in vivo[2].
P32/98 hemifumarate, together with 200 pM GLP-1, (10 μM; 3 h) shows no significant inhibition of sodium re-absorption in porcine proximal tubular cells[2].
P32/98 hemifumarate (10 μM; 96 h) does not influence the mRNA expression of GLP-1R, DPPIV, Na+/H+exchanger isoform 3 (NHE3), sodium-dependent glucose transporter slc5a1, slc5a2 (SGLT1, 2)[2].

Cell Cytotoxicity Assay[2]

Cell Line: Porcine proximal tubular cells
Concentration: 10 μM
Incubation Time: 96 hours
Result: Showed no toxic.
体内研究
(In Vivo)

P32/98 hemifumarate (25 mg/kg; i.g.; once daily) long-time treatment significantly improves the glucose tolerance in Zucker diabetic fatty rats, a model of IGT (impaired glucose tolerance)[3].

Animal Model: Zucker diabetic fatty rat[3]
Dosage: 25 mg/kg
Administration: Oral gavage; once daily
Result: Significantly improved the glucose tolerance in Zucker diabetic fatty rats.
分子量

260.36
Formula

C9H18N2OS.1/2C4H4O4
CAS 号

251572-86-8
中文名称

异亮氨酸噻唑烷半富马酸盐
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
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