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Fluphenazine decanoate dihydrochloride
本半岛bd体育手机客户端 不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Fluphenazine decanoate dihydrochloride图片
CAS NO: 2376-65-0
包装与价格：
包装 价格(元)
100mg 电议
250mg 电议
500mg 电议

半岛bd体育手机客户端 名称
氟奋乃静癸酸酯（二盐酸化物；二氢氯化物）
半岛bd体育手机客户端 介绍
Fluphenazine decanoate dihydrochloride 是一种多巴胺 D2受体抑制剂和吩噻嗪类精神安定剂 ( neuroleptic)。Fluphenazine decanoate dihydrochloride可用于精神分裂症的研究。
生物活性

Fluphenazine decanoate dihydrochloride is adopamineD2receptorinhibitor, is a long-acting phenothiazineneuroleptic. Fluphenazine can be used for schizophrenia research[1][2][3].
IC50& Target

D2Receptor
体外研究
(In Vitro)

Fluphenazine decanoate dihydrochloride shows activity againstT. gondiiin human fibroblast cell cultures with an IC50value of 1.7 mM[1].
体内研究
(In Vivo)

Fluphenazine decanoate dihydrochloride (0.22 mg/kg and followed by 0.33 mg/kg; i.m.; 8 times every 3 weeks), as an antipsychotic, increases sensitivity to dopamine on monkey model following extended treatment[2].
Fluphenazine decanoate dihydrochloride (25 mg/kg; i.m.; 6 times every 3 weeks; 24 weeks) induces mouth movements in the rat, serves as a pharmacological model of human tardive dyskinesia[3].
Fluphenazine decanoate dihydrochloride (1, 2, 3 mg/kg/d; s.c.; 60 d) shows antifertility effects and induces hyperprolactinemia concomitant with gonadotropin suppression in adult male rat[4].

Animal Model: Cebus apella monkey[2]
Dosage: 0.22 mg/kg and followed by 0.33 mg/kg
Administration: Intramuscular injection; 8 times per 3 weeks; 0.22 mg/kg for 63 weeks and 0.33 mg/kg for 6 weeks
Result: Decreased the aggressiveness composite behavioral variables (CBV).
Resulted stereotypic behavior induced by agonist and decreased prolactin response to AMPH.
Animal Model: Male Sprague-Dawley rats (250 g)[3]
Dosage: 25 mg/kg
Administration: Intramuscular injection into the hind limb; 24 weeks
Result: Resulted in spontaneous vacuous chewing mouth movements and jaw tremor.
Animal Model: Adult male rats[4]
Dosage: 1, 2, 3 mg/kg/d
Administration: Subcutaneous injection between 10:00-12:00 h; 60 days
Result: Increased serum prolactin level and suppressed serum LH and FSH levels at day 60.
Increased hypothalamic tyrosine hydroxylase levels, enhanced chromatin decondensation, and resulted DNA denaturation.
Clinical Trial
分子量

664.69
Formula

C32H46Cl2F3N3O2S
CAS 号

2376-65-0
中文名称

氟奋乃静癸酸酯（二盐酸化物；二氢氯化物）
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
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