Ryanodine is a cell permeantryanodine receptormodulator. Ryanodine can either stimulate or inhibit Ryanodine-mediated Ca²⁺release depending on its concentrations. Poisonous diterpenoid found inRyania speciosa.

Ryanodine receptor^[1]

Ryanodine (100-5000 nM, 30-120 mintutes) irreversibly depresses twitch and tetanic tension of both fast and slow muscle in a dose-related manner^[1].

At concentrations above 250 nM, ryanodine induces a slowly developing, dose dependent contracture which could not be blocked by 5 mMCo^2+[1].

493.55

Solid

C₂₅H₃₅NO₉

15662-33-6

• Terpenoids
• Diterpenoids

• Plants
• other families
• Ryania speciosa

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