Delafloxacin (RX-3341; WQ-3034; ABT492) 是一种广谱氟喹诺酮类抗生素。
| Cas No. |
189279-58-1 |
| 别名 |
德拉沙星; RX-3341; WQ-3034; ABT492 |
| 化学名 |
1-(6-amino-3,5-difluoropyridin-2-yl)-8-chloro-6-fluoro-7-(3-hydroxyazetidin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid |
| Canonical SMILES |
ClC1=C(N(C2=NC(N)=C(F)C=C2F)C=C(C(O)=O)C3=O)C3=CC(F)=C1N4CC(O)C4 |
| 分子式 |
C18H12ClF3N4O4 |
| 分子量 |
440.76 |
| 溶解度 |
DMSO: 0.5 mg/ml |
| 储存条件 |
Store at -20℃ |
| General tips |
For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition |
Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 半岛bd体育手机客户端 描述 |
Description: IC50 Value: MICs ranging from 0.0078 to 0.125 micro g/ml for levofloxacin-resistant Streptococcus pneumoniae strains [1] ABT-492 was more potent against quinolone-susceptible and -resistant gram-positive organisms, had activity similar to that of ciprofloxacin against certain members of the family Enterobacteriaceae, and had comparable activity against quinolone-susceptible, nonfermentative, gram-negative organisms. in vitro: ABT-492 exhibited excellent in vitro activities against all 326 aerobic and anaerobic antral puncture sinus isolates tested with MICs (in micrograms per milliliter) at which 90% of the isolates tested were inhibited as follows: Haemophilus influenzae, 0.001; Moraxella catarrhalis, 0.008; and Streptococcus pneumoniae, 0.015 [2]. ABT-492 was as active as trovafloxacin against Chlamydia trachomatis, indicating good intracellular penetration and antibacterial activity [3]. in vivo: N/A Clinical trial: N/A |
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