MC-Val-Cit-PAB-DX8951 (MC-Val-Cit-PAB-DX8951) 是一种用于 ADC 的药物-接头偶联物。 MC-Val-Cit-PAB-DX8951 由 DNA 拓扑异构酶 I DX-8951 和组织蛋白酶可切割的 ADC 接头组成。
Cas No. |
2504068-28-2 |
别名 |
MC-Val-Cit-PAB-DX8951 |
分子式 |
C53H60FN9O12 |
分子量 |
1034.1 |
储存条件 |
4°C, away from moisture |
General tips |
For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition |
Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
半岛bd体育手机客户端 描述 |
MC-Val-Cit-PAB-DX8951 is a drug-linker conjugate for ADC. MC-Val-Cit-PAB-DX8951 is composed of a DNA topoisomerase I DX-8951 and a cathepsin cleavable ADC linker. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. [1]. Anish Thomas, et al. Antibody-drug conjugates for cancer therapy. Lancet Oncol. 2016 Jun;17(6):e254-e262. |