CAS NO: | 1189767-28-9 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
10mg | 电议 |
25mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
500mg | 电议 |
1 g | 电议 |
生物活性 |
Osoresnontrine (BI-409306) is a potent and selectivePDE9Ainhibitor, with anIC50of 52 nM, and shows weak activity against other PDEs, such as PDE1A (IC50, 1.4 μM), PDE1C (IC50, 1.0 μM), PDE2A, PDE3A, PDE4B, PDE5A, PDE6AB, PDE7A, and PDE10A (IC50all >10 μM); Osoresnontrine can be used in the research of memory enhancement in CNS disorders. |
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IC50& Target[1] |
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体外研究 (In Vitro) |
Osoresnontrine is a potent and selective PDE9A inhibitor, with an IC50of 52 nM, and shows weak activity against other PDEs, such as PDE1A (IC50, 1.4 μM), PDE1C (IC50, 1.0 μM), PDE2A, PDE3A, PDE4B, PDE5A, PDE6AB, PDE7A, and PDE10A (IC50all >10 μM), and has no obvious effect on 95 non-PDE targets at 10 μM. Osoresnontrine enhances long-term potentiation (LTP) in rat hippocampal slices[1].
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Clinical Trial |
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分子量 |
311.34 |
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性状 |
Solid |
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Formula |
C16H17N5O2 |
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CAS 号 |
1189767-28-9 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
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溶解性数据 |
In Vitro:
DMSO : ≥ 75 mg/mL(240.89 mM) *"≥" means soluble, but saturation unknown.
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In Vivo:
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