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Clenbuterol
本半岛bd体育手机客户端 不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Clenbuterol图片
CAS NO: 37148-27-9
包装与价格：
包装 价格(元)
100mg 电议
250mg 电议
500mg 电议

半岛bd体育手机客户端 名称
NAB-365
半岛bd体育手机客户端 介绍
Clenbuterol (NAB-365) 是一种 β2-肾上腺素能受体激动剂， EC50为 31.9 nM。Clenbuterol 有效抑制脂多糖 (LPS) 诱导的 TNF-α 和 IL-1β 释放。Clenbuterol 可以抑制炎症过程。Clenbuterol 可用作支气管扩张剂。
生物活性

Clenbuterol (NAB-365) is aβ2-adrenergic receptoragonist with anEC50of 31.9 nM[1]. Clenbuterol is a very potent inhibitor of the lipopolysaccharide (LPS)-induced release of TNF-α and IL-1β. Clenbuterol can inhibit the inflammatory process. Clenbuterol is a bronchodilator[2].
体外研究
(In Vitro)

Clenbuterol (NAB-365) is a selective β2-adrenergic agonist (β2/β1 ratio = 4.0). Clenbuterol is a very potent inhibitor of the lipopolysaccharide (LPS)-induced release of TNF-α and IL-1β. Clenbuterol can inhibit the inflammatory process[2].
Clenbuterol (10-200 μM; for 24 or 48 hours) decreases the viability of C2C12 myoblasts. Clenbuterol (100 μM) significantly decreases DNA synthesis. Clenbuterol (100 μM; for 12 h) increases the proportion of cells in G0/G1 phase. Clenbuterol treatment delays cell cycle progression. Clenbuterol (100 μM) induces cell cycle arrest, but not apoptosis, in C2C12 myoblasts[3].

Cell Viability Assay[3]

Cell Line: C2C12 cells.
Concentration: 0, 10, 100, and 200 μM.
Incubation Time: 24 and 48 hours.
Result: Treatment reduced viability of C2C12 cells for 24 and 48 h.
体内研究
(In Vivo)

Treatment with Clenbuterol increases survival, rescues abnormalities in respiratory function and social recognition, and improves motor coordination in young maleMecp2-null (Mecp2–/y) mice[4].
Clenbuterol is a bronchodilator. Clenbuterol (90 μg) is administered intratracheally to five horses. Peak serum concentrations of ~230 pg/mL are detected 10 min after administration, dropping to ~50 pg/mL within 30 min and declining much more slowly thereafter. Intratracheal administration of clenbuterol shortly before race time can be detected with this serum test[5].

Animal Model: MaleMecp2–/yand femaleMecp2–/+mice[4]
Dosage: 5 or 0.1 mg/kg.
Administration: Injected i.p.; daily for 5 d, followed by a 2-d off period, repeated weekly
Result: Significantly improved the phenotype during the second but not first day of testing, implying a modest effect on motor coordination in Mecp2-null mice.
分子量

277.19
Formula

C12H18Cl2N2O
CAS 号

37148-27-9
中文名称

克仑特罗
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
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