Oroxylin A is a natural active flavonoid with strong anticancer effects. IC50 value: Target: In vitro: Oroxylin A suppressed the MDM2-mediated degradation of p53 via downregulatingMDM2transcription in wt-p53cancercells [1]. Oroxylin A remarkably reduced the generation of lactate and glucose uptake under hypoxia in HepG2 cells, inhibited HIF-1α expression and its stability [2]. Oroxylin A promotes superoxide dismutase (SOD2) gene expression through SIRT3-regulated DNA-binding activity of FOXO3a and increases the activity of SOD2 by promoting SIRT3-mediated deacetylation [3]. In vivo: Oroxylin A inhibited the tumor growth of nude mice-inoculated MCF-7 or HCT116 cells. The expression ofMDM2protein in tumor tissue was downregulated by oroxylin A as well [1].

284.26

Solid

C₁₆H₁₂O₅

480-11-5

千层纸素A

• Flavonoids
• Flavones

• Phenols
• Polyphenols

• Plants
• Bignoniaceae
• Oroxylum indicum(Linn.) Bentham ex Kurz

Room temperature in continental US; may vary elsewhere.

DMSO : ≥ 32 mg/mL(112.57 mM)

*"≥" means soluble, but saturation unknown.

请根据半岛bd体育手机客户端 在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的半岛bd体育手机客户端 失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。