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Anticancer agent 76
本半岛bd体育手机客户端 不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Anticancer agent 76图片
CAS NO: 2448091-11-8
包装与价格：
包装 价格(元)
100mg 电议
250mg 电议
500mg 电议

半岛bd体育手机客户端 介绍
Anticancer agent 76 (Compound CT2-3) 是一种抗癌剂。Anticancer agent 76 能显著抑制人 NSCLC 细胞增殖，诱导细胞周期阻滞、 ROS生成和细胞凋亡（ apoptosis）。
生物活性

Anticancer agent 76 (Compound CT2-3) is an anticancer agent. Anticancer agent 76 significantly inhibits the proliferation of human NSCLC cells, induces cell cycle arrest, causesROSgeneration and induces cellapoptosis[1].
体外研究
(In Vitro)

Anticancer agent 76 (Compound CT2-3) (0-80 μM, 24 h) inhibits the proliferation of human NSCLC cells[1].
Anticancer agent 76 (40 μM, 24 h) arrests cell cycle at G1 phase, induces apoptosis and ROS, suppresses the expression of c-Myc and topoisomerases in NSCLC cells[1].

Cell Proliferation Assay[1]

Cell Line: A549 and H460
Concentration: 0, 10, 20, 40, 60 and 80 μM
Incubation Time: 24 h
Result: Inhibited the proliferation with IC50values of 41.63 μM and 38.03 μM against A549 and H460 cells, respectively.

Cell Cycle Analysis[1]

Cell Line: H460
Concentration: 40 μM
Incubation Time: 24 h
Result: Resulted in increasing cell populations at the G1 phase, down-regulated CDK4, CDK6 and cyclin D1.

Apoptosis Analysis[1]

Cell Line: A549 and H460
Concentration: 20 μM and 40 μM
Incubation Time: 24 h
Result: Induced apoptosis.

Western Blot Analysis[1]

Cell Line: H460 cell
Concentration: 40 μM
Incubation Time: 24 h
Result: Down-regulated mRNA of TOP2B, TOP3B and c-Myc.
分子量

543.67
Formula

C32H33NO5S
CAS 号

2448091-11-8
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
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