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Selegiline
本半岛bd体育手机客户端 不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Selegiline图片
CAS NO: 14611-51-9
包装与价格：
包装 价格(元)
100mg 电议
250mg 电议
500mg 电议

半岛bd体育手机客户端 名称
司来吉兰
Deprenyl
(-)-Selegiline
(-)-Deprenyl
半岛bd体育手机客户端 介绍
Selegiline (Deprenyl) 是一种有效、选择性和不可逆的 MAO-B抑制剂， IC50值为 51 nM。Selegiline 对 MAO-B 的选择性比 MAO-A 高 450 倍 (IC 50=23 μM)。Selegiline 可用于帕金森氏病、阿尔茨海默病和重度抑郁症的研究。
生物活性

Selegiline (Deprenyl) is a potent, selective and irreversible inhibitor ofMAO-B, with anIC50of 51 nM. Selegiline exhibits 450-flod selectivity forMAO-BoverMAO-A(IC50=23 μM). Selegiline can be used for the research of Parkinson's disease, Alzheimer's disease and major depressive disorder[1][2][3].
IC50& Target[1]

MAO-B

51 nM (IC50)
体外研究
(In Vitro)

Selegiline (1 nM-1 μM) inhibits recombinant human MAO-B in a concentration-dependent manner[1].
Selegiline (10 mM) increases the efflux of norepinephrine (NE), dopamine (DA) and serotonin (5-HT) from the rat hypothalamus in vitro. Selegiline inhibits the efflux of dihydroxyphenylacetic acid (DOPAC) and 5-hydroxyindoleacetic acid (5-HIAA) in a dose-dependent manner[3].
体内研究
(In Vivo)

Selegiline (1 mg/kg; i.p. daily for 24 days) reduces Cocaine self-administration of mice and does not affect Cocaine-caused body weight loss. Selegiline reduces 3,4-dihydroxyphenylacetic acid (DOPAC) and 5-hydroxyindoleacetic acid (5-HIAA) concentrations in frontal cortex[4].

Animal Model: Male C57BL/6J mice (20-22 g)[4]
Dosage: 1 mg/kg
Administration: I.p. daily for 24 days
Result: Single injection did not acutely affect mouse locomotor activity.
14 consecutive days administration did not affect food reward.
Reduced Cocaine self-administration, and reduced DOPAC and 5-HIAA concentrations in frontal cortex.
分子量

187.28
Formula

C13H17N
CAS 号

14611-51-9
中文名称

司来吉兰
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
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