| CAS NO: | 209248-71-5 |
| 包装 | 价格(元) |
| 10mM (in 1mL Water) | 电议 |
| 5mg | 电议 |
| 25mg | 电议 |
| 50mg | 电议 |
| Cas No. | 209248-71-5 |
| 别名 | Ile-Pro-Ile TFA |
| Canonical SMILES | CC[C@H](C)[C@@H](C(O)=O)NC([C@H]1N(C([C@H]([C@@H](C)CC)N)=O)CCC1)=O.OC(C(F)(F)F)=O |
| 分子式 | C19H32F3N3O6 |
| 分子量 | 455.47 |
| 溶解度 | Water : ≥ 77.5 mg/mL (170.15 mM) |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 半岛bd体育手机客户端 描述 | Diprotin A (TFA) is an inhibitor of dipeptidyl peptidase IV (DPP-IV). Diprotin A increases the phosphorylation of Src and vascular endothelial-cadherin (VE-cadherin) in human endothelial cells and disrupts endothelial cell-to-cell junctions, which are attenuated by CXCR4 (receptor of SDF-1α)-blocker or Src-inhibitor[1]. In the model of retinopathy of prematurity, Diprotin A increases not only retinal vascularity but also leakage. Additionally, in the murine diabetic retinopathy model, Diprotin A increases the phosphorylation of Src and VE-cadherin and aggravates vascular leakage in the retinas. Collectively, Diprotin A induces vascular leakage by augmenting the SDF-1α/CXCR4/Src/VE-cadherin signaling pathway[1]. [1]. Lee CS, et al. Dipeptidyl Peptidase-4 Inhibitor Increases Vascular Leakage in Retina through VE-cadherin Phosphorylation. Sci Rep. 2016 Jul 6;6:29393. |
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