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Quinidine Monosulfate
本半岛bd体育手机客户端 不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Quinidine Monosulfate图片
CAS NO:50-54-4
包装与价格：
包装价格(元)
100mg电议
250mg电议
500mg电议

半岛bd体育手机客户端 介绍
Quinidine Monosulfate 是一种抗心律失常剂。Quinidine Monosulfate 是一种有效的、具有口服活性的、选择性的细胞色素 P450db (cytochrome P450db) 抑制剂，也是 K+通道 (K+channel) 的有效阻断剂，其IC50值为 19.9 μM，也可诱导凋亡。Quinidine Monosulfate 也可用作疟疾的研究。
生物活性

Quinidine Monosulfate is an antiarrhythmic agent. Quinidine Monosulfate is a potent, orally active, selectivecytochrome P450dbinhibitor. Quinidine Monosulfate is also aK+channelblocker with anIC50of 19.9 μM, and can induceapoptosis. Quinidine Monosulfate can be used for malaria research[1][2][3][4].

体外研究
(In Vitro)

Quinidine Monosulfate shows cytotoxicity against MES-SA cells, and induces apoptosis[4].

Cell Cytotoxicity Assay[4]

Cell Line:MES-SA and MESSA/DX5 cells
Concentration:10 μM
Incubation Time:24 hours
Result:Showed cytotoxicity against MES-SA cells in a concentration-dependent manner.

Apoptosis Analysis[4]

Cell Line:MES-SA and MESSA/DX5 cells
Concentration:10 μM
Incubation Time:24 hours
Result:Increased the apoptotic portion sub-G1 DNA contents induced by paclitaxel, while paclitaxel had no effect on sub-G1 DNA contents undergoing apoptosis.
体内研究
(In Vivo)

Quinidine Monosulfate shows effects on the PTZ-induced seizure threshold[5].

Animal Model:Male mice of the NMRI strain (age 5-6 weeks and weight 25-30 g)[5]
Dosage:10, 20, and 30 mg/kg
Administration:Intraperitoneal injection; 10, 20, and 30 mg/kg; once
Result:Increased the threshold dose for the onset to tonic hind limb extension at a dose of 30 mg/kg, compared to the saline-treated control group (p<0.05).
Clinical Trial
分子量

373.46

Formula

C20H26N2O6S

CAS 号

50-54-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

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