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UC-1V150
本半岛bd体育手机客户端 不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
UC-1V150图片
CAS NO: 927822-45-5
包装与价格：
包装 价格(元)
100mg 电议
250mg 电议
500mg 电议

半岛bd体育手机客户端 介绍
UC-1V150 是一种特异性 TLR7激活剂，可刺激细胞免疫反应，具有抗肿瘤活性。UC-1V150 可以用于合成 ISAC 分子。
生物活性

UC-1V150 is a specificTLR7(Toll-like receptor) agonist that stimulates cellular immune responses and has anti-tumor activity. UC-1V150 can be used to synthesize ISAC (Immune-Stimulating Antibody Conjugates) molecule[1][2].
IC50& Target

TLR7
体外研究
(In Vitro)

UC-1V150 (0.01-10 μM, 24 hour) can stimulate the release of IL-6 and IL-2 cytokines effectively in bone-marrow-derived macrophages[1].
UC-1V150 (1 μg/mL, 48 hours) can increase the expression of FcγRIIA and FcγRIII while inducing an approximately 1.5-fold increase in macrophage phagocytosis index of target cells in hman monocyte-derived macrophages (hMDM)[2].
体内研究
(In Vivo)

UC-1V150 (intravenous injection, 0.38-38 nM, once) effectively induces release of serum cytokines within a certain concentration range in female C57BL/6 mice (5-6 weeks of age)[1].

Animal Model: Female C57BL/6 mice (5-6 weeks of age)[1]
Dosage: 0.38-38 nM
Administration: Intravenous injection; once
Result: Induced serum cytokine IL-6 levels about 0.1 ng/mL and IL-2 levels about 1.5 ng/mL at the concentration of 38 nM.
分子量

343.34
Formula

C16H17N5O4
CAS 号

927822-45-5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
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