Ridogrel (R 68070) is an orally activecombined thromboxane A2 synthetaseinhibitor and thromboxane A2/prostaglandin endoperoxide receptor blocker. Ridogrel is potent antiplatelet agent. Anti-inflammatory activities^[1][2][3].

In rats, R 68 070 (1.25 mg/kg orally, -2 h) singly prolongs tail bleeding times as much as a combination of TXA2 synthetase inhibition (dazoxiben 10 mg/kg) and TXA2/prostaglandin endoperoxide receptor blockade (BM 13177 40 mg/kg). In dogs, the compound reduces coronary thrombosis induced by electrical damage (1.25 mg/kg i.v.) and prevents the evolution of occlusion/reperfusion-induced arrhythmias into ventricular fibrillation (2.5 mg/kg i.v.)^[2.

366.33

Solid

C₁₈H₁₇F₃N₂O₃

110140-89-1

Room temperature in continental US; may vary elsewhere.

DMSO : 100 mg/mL(272.98 mM;Need ultrasonic)

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