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RFRP-3(human)TFA
本半岛bd体育手机客户端 不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
RFRP-3(human)TFA图片
包装与价格:
包装 价格(元)
100mg 电议
250mg 电议
500mg 电议

半岛bd体育手机客户端 名称
Neuropeptide VF(124-131)(human) TFA
半岛bd体育手机客户端 介绍
RFRP-3 (Neuropeptide VF(124-131))(human) TFA,一种人GnIH 肽同源物,是一种促性腺激素分泌抑制 Ca 2+动员的有效抑制剂。RFRP-3(human) TFA 是一种 NPFF1受体激动剂,它抑制 forskolin (HY-15371) 诱导的 cAMP 生成的 IC 50值为 0.7 nM。
生物活性

RFRP-3 (Neuropeptide VF(124-131))(human) TFA, a humanGnIH peptidehomolog, is a potent inhibitor ofgonadotropin secretionby inhibiting Ca2+mobilization. RFRP-3(human) is aNPFF1 receptoragonist, it inhibits forskolin-induced production of cAMP with an IC50of 0.7 nM[1].

体外研究
(In Vitro)

RFRP-3 TFA efficiently inhibits forskolin-induced production of cAMP with an IC50of 0.7 nM[1].
Scatchard-plot analysis shows that125I-labelled hRFRP-3 has a single class of high-affinity binding sites for the membrane fractions of CHO cells expressing rat OT7T022, the Kdvalue and the Bmaxvalues are 0.19 nM and 1.3 pM, respectively.
RFRP-3 TFA specifically stimulate cells transfected with a new orphan 7TMR, OT7T022, it binds to OT7T022 as a specific ligand with high affinity (Kd= 0.19 nM)[1].
RFRP-3 (10-8to 10-14M) has no effect on LH and FSH levels alone, but when it combines with GnRH, LH and FSH secretion is significantly reduced by the combination[1].

分子量

1083.16

Formula

C47H73F3N14O12

Sequence Shortening

VPNLPQRF-NH2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

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