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Plecanatide acetate

本半岛bd体育手机客户端不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1075732-84-1

包装与价格：

包装	价格(元)
5mg	电议
10mg	电议
50mg	电议
100mg	电议

半岛bd体育手机客户端名称

普卡那肽醋酸盐；醋酸普卡那肽

半岛bd体育手机客户端介绍

Plecanatide acetate 是尿鸟苷蛋白的类似物，是一种具有口服活性的鸟苷酸环化酶 C 受体 ( guanylate cyclase-C (GC-C) receptor) 激动剂，在 T84 细胞中， EC₅₀值为 190 nM。Plecanatide acetate 可用于慢性特发性便秘的研究，在小鼠结肠炎模型中具有抗炎活性。

生物活性

Plecanatide acetate, an analogue of Uroguanylin, is an orally activeguanylate cyclase-C (GC-C) receptoragonist. Plecanatide acetate activates GC-C receptors to stimulate cGMP synthesis with anEC₅₀of 190 nM in T84 cells assay. Plecanatide acetate can be used for the research of chronic idiopathic constipation, and it also shows anti-inflammatory activity in models of murine colitis^[1]^[2]^[3].

IC₅₀& Target

EC50: 190 nM (guanylate cyclase-C receptor, T84 cells)^[1]

体外研究
(In Vitro)

Plecanatide (1 nM-10 μM) activates GC-C receptor to stimulate cGMP synthesis in a dose-dependent manner with EC₅₀of 190 nM in T84 cells^[1].

体内研究
(In Vivo)

Plecanatide (0.5 and 2.5 mg/kg, p.o.) ameliorates spontaneous and chemically induced colitis after treatment for 7 days in BALB/c mice, and 14 days in TCRα^-/-mice^[1].
Plecanatide (0.005-5 mg/kg, once daily for 7 days) also shows anti-inflammatory activity in dextran sulfate sodium (DSS) and trinitrobenzene sulfonic (TNBS)-induced colitis in BDF-1 mice^[1].

Animal Model:	Female BALB/c mice (2-4 month old) are induced colitis by TNBS^[1]
Dosage:	0, 0.5 and 2.5 mg/kg
Administration:	P.o. for 7 days
Result:	Effectively reduced colitis severity scores as compared to vehicle treatment.