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Pheniramine
本半岛bd体育手机客户端 不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Pheniramine图片
CAS NO: 86-21-5
包装与价格：
包装 价格(元)
100mg 电议
250mg 电议
500mg 电议

半岛bd体育手机客户端 名称
Prophenpyridamine
Tripoton
半岛bd体育手机客户端 介绍
Pheniramine (Prophenpyridamine;Tripoton) 是第一代组胺 H1受体拮抗剂，作用于中枢神经系统 (CNS) ，产生镇静、助眠的作用。Pheniramine 也是安全、有效的局部麻醉剂，并有止痒作用。
生物活性

Pheniramine (Prophenpyridamine;Tripoton) is a first-generationhistamine H1 receptorantagonist, acts on the central nervous system (CNS) with sedative and hypnotic effect. Pheniramine displays antitumor effect and induces leukemia cellsapoptosis. Pheniramine is also a safe and effective local anesthetic, with antipruritic effects[1][2][3][4].
IC50& Target

H1Receptor

1.01 mM (IC50)
体外研究
(In Vitro)

Pheniramine inhibits CYP2D6, the specific P450-isozymes, to delay metabolic time and prolong antihistaminic effects[1].
Pheniramine inhibits Ca2+influx into BC3H-1 cells by inhibiting histamine with an IC50value of 1.01 mM and regulates cellular Ca2+transmembrane action[2].
Pheniramine (0.5, 1.0 mM; 24 h) induces cell apoptosis in human T-cell acute lymphoblastic leukemia cell lines[3].
Pheniramine (1 μM-1 mM; 12-48 h) inhibits cell proliferation in a time-dependent manner and shows inhibitory concentration IC50s of 550 μM (CCRF-CEM cells) and 420 μM (Jurkat cells), respectively[3].

Apoptosis Analysis[3]

Cell Line: Human T-cell acute lymphoblastic leukemia cell lines: CCRF-CEM and Jurkat ALL
Concentration: 0.5, 1.0 mM
Incubation Time: 24 hours
Result: Induced cells apoptosis with chromatin condenses and marginalizes, and nuclear debris spreaded into the cytoplasm.

Cell Viability Assay[3]

Cell Line: Human T-cell acute lymphoblastic leukemia cell lines: CCRF-CEM and Jurkat ALL
Concentration: 1 μM-1 mM
Incubation Time: 12, 24, 48 hours
Result: Inhibited cell proliferation and survival in a time- and dose-dependent manner.
体内研究
(In Vivo)

Pheniramine (1.75 μM; i.t.) exerts local anesthesia effect and results spinal block in rats[4].

Animal Model: Sprague–Dawley rats (300-350 g; male)[4]
Dosage: 0.30, 0.60, 0.90, 1.50, 1.75 μM
Administration: Intrathecal injection; one time
Result: Resulted the spinal block and displayed dose-dependent effect.
Showed 100% blockades in motor function, proprioception, and nociception, with full recoveryduration of action about 41, 56, and 88 min, respectively, at 1.75 μM.
分子量

240.34
Formula

C16H20N2
CAS 号

86-21-5
中文名称

非尼拉敏-d4EP杂质A
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
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