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Mongersen
本半岛bd体育手机客户端 不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
CAS NO: 1443994-46-4
包装与价格：
包装 价格(元)
1mg 电议
5mg 电议
10mg 电议

半岛bd体育手机客户端 名称
GED-0301
半岛bd体育手机客户端 介绍
Mongersen (GED-0301) 是一种具有特异性和口服活性的 SMAD7反义寡核苷酸。Mongersen 恢复 TGF-β1 活性，从而抑制炎症信号。Mongersen 可以减轻小鼠的克罗恩病样实验性结肠炎。
生物活性

Mongersen (GED-0301) is a specific and orally active SMAD7 antisense oligonucleotide. Mongersen restoresTGF-β1activity leading to inhibition of inflammatory signals. Mongersen can attenuate Crohn's disease-like experimental colitis in mice[1][2].
体内研究
(In Vivo)

Mongersen (125 μg/mouse; p.o. twice a week for 3 weeks) reduces TNBS- or DSS-induced colonic inflammation and colonic fibrosis of mice[2].

Animal Model: Eight-week-old female BALB/c mice were treated with TNBS[2]
Dosage: 125 μg/mouse
Administration: Oral gavage, twice a week starting from week 5 or week 9 for 3 weeks
Result: Reduced Smad7 protein expression.
Attenuated the ongoing colonic inflammation.
Significantly reduced TNF-α and IL-6 RNA expression.
Attenuated colonic fibrosis.
Clinical Trial
分子量

6584.00
性状

Solid
CAS 号

1443994-46-4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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