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Tetramethylpyrazine
本半岛bd体育手机客户端 不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Tetramethylpyrazine图片
CAS NO: 1124-11-4
包装与价格:
包装 价格(元)
10mM (in 1mL DMSO) 电议
100mg 电议

半岛bd体育手机客户端 介绍
四甲基吡嗪(川芎嗪),一种从川芎中分离出来的烷基吡嗪。
Cas No. 1124-11-4
别名 川芎嗪; Chuanxiongzine; Tetramethylpyrazine
化学名 2,3,5,6-tetramethylpyrazine
Canonical SMILES CC1=C(N=C(C(=N1)C)C)C
分子式 C8H12N2
分子量 136.2
溶解度 DMF: 5mg/mL,DMSO: 5mg/mL,Ethanol: 25mg/mL,Ethanol:PBS (pH 7.2) (1:5): 0.16mg/mL
储存条件 Stored at RT
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
半岛bd体育手机客户端 描述

Tetramethylpyrazine (Ligustrazine), an alkylpyrazine isolated from Ligusticum wallichii (Chuan Xiong)[1], is present in french fries, bread, cooked meats, tea, cocoa, coffee, beer, spirits, peanuts, filberts, dairy products and soy products as fragrance and flavouring ingredienexhibits. Tetramethylpyrazine (Ligustrazine) also has potential nootropic and anti-inflammatory activities in rats[2][3].

Tetramethylpyrazine has been extensively used in China for cardiovascular and cerebrovascular diseases for about 40 years. Because of its effectiveness in multisystem, especially in cardiovascular. Tetramethylpyrazine also has been used in various diseases, such as coronary heart disease, diabetes, cancers, and liver injury[1].

References:
[1]. Zhao Y, et al. Mechanisms and Clinical Application of Tetramethylpyrazine (an Interesting Natural Compound Isolated from Ligusticum Wallichii): Current Status and Perspective. Oxid Med Cell Longev. 2016;2016:2124638.
[2]. Wu W, et al. Tetramethylpyrazine protects against scopolamine-induced memory impairments in rats by reversing the cAMP/PKA/CREB pathway. Behav Brain Res. 2013 Sep 15;253:212-6.
[3]. Kao TK, et al. Tetramethylpyrazine reduces cellular inflammatory response following permanent focal cerebral ischemia in rats. Exp Neurol. 2013 Sep;247:188-201.

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