涓€銆佸熀纭€淇℃伅

鑻辨枃鍚嶏細Capsaicin涓枃鍚嶏細杈ｆ绱?nbsp;CAS鍙凤細404-86-4 鍒嗗瓙寮忥細C18H27NO3
鍒嗗瓙閲忥細305.412 g/mol鎬х姸锛氬浐浣?nbsp; 棰滆壊锛欬/span>White to off-white鐔旂偣锛欬/span>65鈩?lit.)
鍌ㄨ棌鏉′欢锛氬父娓?nbsp;LogP锛?.6

涓枃鍓悕锛氾紙澶╃劧锛夎荆妞掔礌锛屽ぉ鐒惰荆妞掔⒈

鑻辨枃鍓悕锛欬/span> Axsain, Capsaicin,锛?E锛?, Capsaicine, E-Capsaicine, Capsin P50, Capzasin-HP, Dolenon, Mioton, Ratden PE 40, Togarashi Orenji, Zostrix, CAP, trans-8-methyl-N-vanillyl-6-nonenamide

婧惰В搴︼細涓嶆憾浜庡喎姘达紝寰憾浜庢祿鐩愰吀锛屾憾浜庣煶娌归啔锛屾槗婧朵簬閱囥€侀啔銆佽嫰锛屽井婧朵簬浜岀～鍖栫⒊

浜屻€佷骇鍝佺畝浠婞/span>

杈ｆ绱犳槸涓€绉嶈荆妞掔礌绫荤墿璐ㄣ€傛嵁鎶ラ亾锛岀粧姣涜荆妞掋€佽荆妞掍腑閮藉惈鏈夎荆妞掔礌銆侟span style="font-weight: normal; font-size: 14px; font-family: 寰蒋闆呴粦, Microsoft YaHei;">瀹冨叿鏈夐潪楹婚唹鎬ч晣鐥涜嵂銆佺數鍘嬮棬鎺ч挔绂诲瓙閫氶亾闃绘粸鍓傚拰TRPV1婵€鍔ㄥ墏鐨勪綔鐢ㄣ€侟/span>

杈ｆ绱犳渶甯哥敤浣滃眬閮ㄦ鐥涜嵂锛屽瓨鍦ㄤ簬鍚勭娴撳害鐨勪钩鑶忋€佹恫浣撳拰璐村墏涓紱鐒惰€岋紝瀹冧篃鍙兘瀛樺湪浜庝竴浜涜喅椋熻ˉ鍏呭墏涓€侟span style="font-weight: normal; font-size: 14px; font-family: 寰蒋闆呴粦, Microsoft YaHei;">杩戞湡鑾峰緱FDA鎵瑰噯鐨勮荆妞掔礌鏄 Qutenza锛岃繖鏄竴绉 8% 杈ｆ绱犺创鍓傜毊鑲ょ粰鑽郴缁燂紝鐢ㄤ簬娌荤枟绁炵粡鐥涚浉鍏崇殑绁炵粡鎬х柤鐥涖€侟/span>

涓夈€佽嵂鐞嗘椿鎬?/span>

浣滅敤闈剁偣锛欬/span>

TRPV1 - transient receptor potential cation channel subfamily V member 1 (human) 婵€鍔ㄥ墏

CYP3A4- Cytochrome P450 3A4鎶戝埗鍓侟/span>

PTGS2-Prostaglandin G/H synthase 2 鎶戝埗鍓侟/span>

COX-2-鎶戝埗鍓侟/span>

iNOS-鎶戝埗鍓侟/span>

鑽搧娉ㄥ唽鐘舵€侊細鎵瑰噯涓婂競

鑽墿闈剁偣锛欬/span>

ecto-NOX disulfide-thiol exchanger 2 (ENOX2)

NF-kappaB (NFkB)

Quinolone resistance protein (NorA)

transient receptor potential cation channel subfamily V member 1 (TRPV1)

鍥涖€佽涓氬簲鐢?/span>

FDA鎵瑰噯浣滀负璋冨懗鍓傛垨浣愬墏娣诲姞鍒伴鍝佷腑锛汓/span>

FDA鑽悊鍒嗙被锛氱粏鑳炰粙瀵煎厤鐤[PE]锛涜喅椋熻泲鐧借川[CS]锛涜繃鏁忓師[CS]锛涙鐗╄泲鐧借川[CS]锛涢潪鏍囧噯鍖栭鍝佽繃鏁忓師鎻愬彇鐗[EPC]锛涚粍鑳洪噴鏀惧鍔[PE]锛涙鐗╄泲鐧借川[CS]锛涢潪鏍囧噯鍖栨鐗╄繃鏁忓師鎻愬彇鐗[EPC]

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閴村畾鏂规硶锛氳川璋憋紙MS锛夛紝鏍哥锛圢MR锛夛紱
娓╅Θ鎻愮ず锛氭垜鍙镐骇鍝佺敱CNAS璁ゅ彲瀹為獙瀹よ繘琛屽叏杩囩▼鐩戞帶锛岃鎸夌収浜у搧鍌ㄥ瓨瑕佹眰濡ュ杽淇濆瓨锛屽紑灏佸嵆鐢ㄤ笖鐜伴厤鐜版祴锛汓br/>