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鑻辨枃鍚嶏細Celastrol

涓枃鍚嶏細闆峰叕钘ょ孩绱燑/p>

CAS鍙凤細34157-83-0

鍒嗗瓙寮忥細C29H38O4

鍒嗗瓙閲忥細450.62g/mol

缁撴瀯绫诲瀷锛歍riterpenoids

鎬х姸锛氬浐浣掽/p>

棰滆壊锛氱孩鑹秉/p>

婧惰В搴︼細婧朵簬鐢查唶

鍌ㄨ棌鏉′欢锛氬瘑闂€佸共鐕ャ€佸父娓╅伩鍏変繚瀛楛/p>

LogP锛?.9

涓枃鍓悕锛氬崡铔囪棨绱狅紝鍗楄泧钘ら唶

鑻辨枃鍓悕锛歍ripterin

鏉ユ簮锛氱嫭瀛愯棨銆佺豢鐙瓙钘ゃ€侀浄鍏棨銆佸崡铔囪棨

浜屻€佷骇鍝佺畝浠婞/p>

闆峰叕钘ょ孩绱犳槸涓€绉嶄簲鐜笁钀滅被鍖栧悎鐗╋紝鍙互鏈夋晥鎶戝埗绾跨矑浣撲腑鐨勮剛璐ㄨ繃姘у寲骞舵姂鍒 TNF-伪 璇卞鐨凬FkappaB婵€娲汇€傚彟澶栵紝瀹冨叿鏈夋姉姘у寲鍓傘€佹姉鐐庤嵂銆 鎶戝埗鍓傘€佹姉鑲跨槫鍓傘€丠sp90鎶戝埗鍓傜殑浣滅敤銆侟/p>

涓夈€佽嵂鐞嗘椿鎬?/p>

catechol-O-methyltransferase (COMT)

Enoyl-acyl carrier reductase (FabI)

Heat shock protein 90 (nonspecified subtype)

MYC associated factor X (MAX)

MYC proto-oncogene, bHLH transcription factor (MYC)

鍥涖€佽涓氬簲鐢?/p>

鍖昏嵂棰嗗煙锛氶樋灏旇尐娴烽粯鐥? Alzheimer ' s Dementia锛孉D )娌荤枟锛涙姉鍏宠妭鐐庤嵂鐗╋紱鎶楃檶鑽墿锛涢檷绯栬嵂鐗╋紱鍑忚偉鑽紱甯曢噾妫梾

浜斻€佸叾浠朁br/>鍖呰锛?KG銆?KG銆?KG銆?5KG鎴栨牴鎹鎴烽渶姹傚畾鍒迭br/>渚涘簲鎯呭喌锛氬ぇ閲忕幇璐э紱
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閴村畾鏂规硶锛氳川璋憋紙MS锛夛紝鏍哥锛圢MR锛夛紱
娓╅Θ鎻愮ず锛氭垜鍙镐骇鍝佺敱CNAS璁ゅ彲瀹為獙瀹よ繘琛屽叏杩囩▼鐩戞帶锛岃鎸夌収浜у搧鍌ㄥ瓨瑕佹眰濡ュ杽淇濆瓨锛屽紑灏佸嵆鐢ㄤ笖鐜伴厤鐜版祴锛汓br/>