【化学名称】：CDDO

【同义词【�Bardoxolone; RTA 401; 2-Cyano-3,12-dioxooleana-1,9(11)-dien-28-oic Acid;

【CAS 【� 218600-44-3

【分子式】：C₃₁H₄₁O₄

【外观【�类白色固佒�/span>

【熔点】：>280oC (dec.)

【分子量【�491.66

【存储】：-20?C Freezer

【溶解性【�溶于氯仿（略），乙酸乙酯（略），甲醇，DMF筈�/span>

【应用】：CDDO is a synthetic oleanane triterpenoid that exerts multifunctional activities in the control of cellular growth and differentiation. CDDO is capable of activating the transcription factor peroxisome proliferator activator receptor-γ(PPARγ), its apoptotic effects in malignant cells have been shown to occur independently of PPARγ. Bardoxolone was developed as an potential drug for the improvement of hyperglycemia, proteinuria, glomerulus structure, serum creatine, which may in turn be beneficial to treat diabetic kidney diseases, cancer and thromboembolic events.

CDDO是一种合成的通过多功能活动控制细胞生长和分化的齐墩果烷型三萜，已被被开发为一种改善高血糖、蛋白尿症、肾小球结构，血清肌酸激酶的潜在性药物，这可能有利于治疗糖尿病、肾脏疾病、癌症和血栓疾病等、�/span>

CDDO ＇�span style="font-size: 16px; font-family: Calibri;">2-氰基-3＋�span style="font-size: 16px; font-family: Calibri;">12-二氧齐墩果烷-1＋�span style="font-size: 16px; font-family: Calibri;">9(11)-二烯-28-酸）及其类似物的合成、药理和临床有了较大的进展、�span style="font-size: 16px; font-family: Calibri;">CDDO及其衍生物是以齐墩果酸为先导物和前体发展起来的，在抗炎和抗癌方面展现出巨大潜力、�span style="font-size: 16px; font-family: Calibri;">CDDO-Me已经进入III临床亍�span style="font-size: 16px; font-family: Calibri;">II型糖尿病人的慢性肾病治疗，�?span style="font-size: 16px; font-family: Calibri;">IIb期临床试验时发现，采�?span style="font-size: 16px; font-family: Calibri;">CDDO-Me治疗组的肾小球滤过率有显著的提高＋�span style="font-size: 16px; font-family: Calibri;">CDDO-Im在抗癌方面具有较好的效果�?nbsp;