鍩哄洜鍚嶏細

CACNA1A

浜у搧鍒悕锛欬p style="text-indent: 2em;">APCA锛 BI锛 CACNL1A4锛 CAV2.1锛 DEE42锛 EA2锛 EIEE42锛 FHM锛 HPCA锛 MHP锛 MHP1锛 SCA6锛 CACNA1A锛 calcium voltage-gated channel subunit alpha1 A锛 calcium voltage-gated channel subunit alpha1 A锛 voltage-dependent P/Q-type calcium channel subunit alpha-1A锛 brain calcium channel 1锛 brain calcium channel I锛 calcium channel, L type, alpha-1 polypeptide锛 calcium channel, voltage-dependent, P/Q type, alpha 1A subunit锛 fetal brain Ca2+ voltage-gated channel alpha1A pore-forming subunit锛 voltage-gated calcium channel subunit alpha Cav2.1锛 鐢靛帇渚濊禆鎬ч挋閫氶亾Cav2.1锛

鑳屾櫙淇℃伅锛欬div style="text-indent: 2em;">Cav2.1 is a voltage-sensitive calcium channels (VSCC) which belongs to the calcium channel alpha-1 subunit family. Cav2.1 mediates the entry of calcium ions into excitable cells and is also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. Cav2.1 (isoform alpha-1A) gives rise to P and/or Q-type calcium currents. Voltage-dependent calcium channels are multisubunit complexes, consisting of alpha-1, alpha-2, beta and delta subunits in a 1:1:1:1 ratio. The channel activity is directed by the pore-forming and voltage-sensitive alpha-1 subunit. In many cases, this subunit is sufficient to generate voltage-sensitive calcium channel activity. The auxiliary subunits beta and alpha-2/delta linked by a disulfide bridge regulate the channel activity.