重组ZNHIT2蛋白
半岛bd体育手机客户端 名称
Recombinant ZNHIT2
Recombinant zinc finger HIT-type containing 2 protein
半岛bd体育手机客户端 介绍
基因名:
ZNHIT2 半岛bd体育手机客户端 别名: C11orf5; FON; ZNHIT2; zinc finger HIT-type containing 2; zinc finger HIT-type containing 2; zinc finger HIT domain-containing protein 2; zinc finger, HIT domain containing 2; zinc finger, HIT type 2; ZNHIT2蛋白; 背景信息:
ZNHIT2 (zinc finger, HIT-type containing 2), also known as FON, is a 403 amino acid protein that is highly expressed in the seminiferous tubules of testis, with low expression in other tissues. Containing one HIT-type zinc finger, ZNHIT2 is encoded by a gene that maps to human chromosome 11, which comprises approximately 4% of human genomic DNA and is considered a gene and disease association dense chromosome. The chromosome 11 encoded Atm gene is important for regulation of cell cycle arrest and apoptosis following double strand DNA breaks. Atm mutation leads to the disorder known as ataxia-telangiectasia. The blood disorders Sickle cell anemia and thalassemia are caused by HBB gene mutations, while Wilms' tumors, WAGR syndrome and Denys-Drash syndrome are associated with mutations of the WT1 gene. Jervell and Lange-Nielsen syndrome, Jacobsen syndrome, Niemann-Pick disease, hereditary angioedema and Smith-Lemli-Opitz syndrome are also associated with defects in chromosome 11-encoded genes.
标签:His-tag
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