重组细胞膜钙ATP酶4蛋白
半岛bd体育手机客户端 名称
重组细胞膜钙ATP酶4B蛋白
Recombinant ATP2B4
半岛bd体育手机客户端 介绍
基因名:
ATP2B4 半岛bd体育手机客户端 别名: ATP2B2; MXRA1; PMCA4; PMCA4b; PMCA4x; ATP2B4; ATPase plasma membrane Ca2+ transporting 4; ATPase plasma membrane Ca2+ transporting 4; plasma membrane calcium-transporting ATPase 4; ATPase, Ca++ transporting, plasma membrane 4; matrix-remodeling-associated protein 1; sarcolemmal calcium pump; 细胞膜钙ATP酶4; 细胞膜钙ATP酶4B; 钙离子转运ATP酶B4(ATP2B4); 背景信息:
Plasma membrane-type Ca2+-ATPases (PMCAs) mediate the export of bivalent calcium ions from eukaryotic cells. As members of the P class of ion-motive ATPases, PMCAs are a functionally diverse group of proteins that are derived from alternatively spliced transcripts originating from four distinct genes, PMCA1, 2, 3, and 4. The expression of different PMCA isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, and with respect to the physiological needs of specific cell and tissue types. Spatial and temporal rates of resting intracellular Ca2+ concentrations and Ca2+ signaling in eukaryotic cells are dependent on the array of PMCA isoforms that are expressed in concert with the rate of Ca2+ export. PMCA3 expression is confined to brain and skeletal muscle. The PMCA4 gene is located on human chromosome 1q25 and is ubiquitously expressed.
标签:His-tag
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