PEG淇グ鏄竴涓皢PEG鑱氬悎鐗╀笌鍖呮嫭鍒嗗瓙锛屽ぇ鍒嗗瓙锛岄绮掞紝琛ㄩ潰鍦ㄥ唴鐨勫簳鐗╁垎瀛愬舰鎴愬叡浠烽敭鐨勫寲瀛﹁繃绋嬨€傜敱浜庝笉鍚屽簳鐗╂椿鎬т綅鐐圭殑涓嶅悓锛孭EG淇グ涓嶅悓鐨勫畼鑳藉洟闇€瑕佷笉鍚岀殑PEG璇曞墏銆備互涓嬪垪涓句簡涓€浜涙枃鐚姤閬撶殑甯哥敤鐨刌areBio-PEG淇グ鍖栧妗堜緥銆侟/p>
涓€銆佽兒鐨凕/strong>PEG淇グ鍜孅/strong>N-绔熀鑱氫箼浜岄唶鎺ユ灊:涓庣敓鐗╁ぇ鍒嗗瓙鐨勬皑鍩哄弽搴旂殑PEG璇曞墏
PEG-NHS |
鑱氫箼浜岄唶缇ч吀鐨凕/span>N-缇熷熀鐞ョ弨閰颁簹鑳裹/span>(NHS)娲绘€ч叝鍙互鍜岃禆姘ㄩ吀鐨勮兒鍩哄洟鍙嶅簲銆傝鍋跺悎鍙嶅簲鍙渶瑕佸湪娓╁拰鐨勫弽搴旀潯浠讹紝pH 7-9锛屼綆娓?/span>(5-25掳C)涓嬪弽搴旇緝鐭殑鏃堕棿銆傚舰鎴愮敓鐞嗙ǔ瀹氱殑閰拌兒閿€侟/span> |
PEG-Aldehyde |
鍦ㄧ〖姘㈠寲閽犲拰姘板熀纭兼阿鍖栭挔绛夎繕鍘熷墏瀛樺湪鐨勬潯浠朵笅锛屼集鑳洪€氳繃杩樺師鎬ф皑鍖栫敓鎴愪徊鑳恒€侟/span>pH鍊煎浜庤繕鍘熸皑鍖栧崄鍒嗛噸瑕併€傝仛涔欎簩閱嘃/span>-閱涙槸涓€绉岦/span>N-绔熀鑱氫箼浜岄唶淇グ鎺ユ灊寰堝ソ鐨勮瘯鍓傘€侟/span> |
PEG Epoxide |
浜叉牳鍔犳垚 |
PEG-Isothiocyanate |
涓庤兒鍙嶅簲鐢熸垚绋冲畾鐨勭～鑴层€侟/span> |
PEG-COOH |
閫氬父璇ラ吀闇€瑕佽婵€娲伙紝渚嬪NHS閰€侟/span> |
PEG-NPC |
鍦ㄥ悎閫傜殑鏉′欢涓嬶紝鑳哄彲浠ュ拰NPC瀹樿兘鍥慨楗扮殑PEG鍙嶅簲銆侟/span> |
PEG-Acrylate |
鑳哄拰涓欑儻閰搁叝鐨勮繄鍏嬪皵鍔犳垚鍙嶅簲锛屾槸鐩稿杈冩參鐨勫弽搴斻€侟/span> |
浜屻€佺晶鍩虹殑PEG淇グ:鍦ㄥ伓鑱斿墏锛屼緥濡侱CC(N,N'-浜岀幆宸卞熀纰充簩浜氳兒)鍜孍DIC瀛樺湪鐨勬潯浠朵笅锛 PEG璇曞墏涓庣晶閰稿弽搴擖/p>
PEG-Amine |
鍦?/span>DCC鎴朁/span>EDC鍋跺悎鏉′欢涓嬪弽搴旂敓鐢熸垚閰拌兒 |
PEG-Hydrazide |
鍦ㄥ急閰告€т笅缁忚繃EDIC婵€娲伙紝铔嬬櫧璐ㄧ殑缇у熀鍩哄洟鍙互寰堝鏄撲笌PEG-閰拌偧鍙嶅簲锛屽悓鏃跺湪姝ょ壒鍒潯浠朵笅锛屾墍鏈夎瘯鍓傜殑姘ㄥ熀鍩哄洟淇濇寔闈炴椿鍔ㄧ姸鎬併€侟/span> |
PEG-Halide/sulfonate |
PEG-鍗ゅ寲鐗?/span>(姘寲鐗?/span>,婧村寲鐗?/span>,纰樺寲鐗?/span>,瀵圭敳鑻：閰搁叝鍜岀敳纾洪吀閰?/span>)鍜屽幓璐ㄥ瓙鍖栫殑缇у熀锛屽嵆-COO-鐩愬弽搴斻€侟/span> |
涓夈€佸矾鍩虹殑PEG淇グ:宸熀鐨凱EG淇グ鏄拡瀵圭敓鐗╁垎瀛愮殑鑷敱纭唶锛屼緥濡傚崐鑳辨皑閰伏/p>
PEG-Maleimide |
纭唶涓嶞/span>C=C鍙岄敭鍦ㄩ┈鏉ラ叞浜氳兒鐜瓨鍦ㄦ椂锛岄€氳繃杩堝厠灏斿姞鎴愮敓鎴愮敓鐞嗙ǔ瀹氱殑閿悎銆傛渶浣崇殑鍙嶅簲鏉′欢鏄?/span>pH 8銆侟/span> |
PEG-OPSS |
鐢熸垚浜岀～鍖栫墿S-S閿?/span>,涔熷彲浠ラ€氳繃纭兼阿鍖栭挔鍜岀～浠ｄ箼閱囪兒绛夎繕鍘熷墏閫嗚浆鍙嶅簲 |
PEG-Vinylsulfone |
纭唶涓嶞/span>C=C鍙岄敭鍦ㄩ┈鏉ラ叞浜氳兒鐜瓨鍦ㄦ椂锛岄€氳繃杩堝厠灏斿姞鎴愮敓鎴愮敓鐞嗙ǔ瀹氱殑鍖栧閿€侟/span> |
PEG-Thiol |
褰㈡垚姘у寲鎬х殑浜岀～鍖栫墿S-S閿?/span> |
PEG-Halide |
PEG-鍗ゅ寲鐗?/span>(姘寲鐗?/span>,婧村寲鐗?/span>,纰樺寲鐗?/span>,瀵圭敳鑻：閰搁叝鍜岀敳纾洪吀閰?/span>)鍜岃嚜鐢辩～閱囥€傜涔欓吀閰垨纰樹箼閰拌兒瀵逛簬鑷敱纭唶鐨勬椿鎬ф瀬寮恒€侟/span> |
鍥涖€佺緹鍩虹殑PEG淇グ
PEG-Isocyanate |
缇熷熀鍩哄洟涓嶞/span>PEG-NCO鍙嶅簲,涓嶈繃闇€瑕佹瘮杈冪壒娈婄殑鍙嶅簲鏉′欢 |
PEG-NPC |
缇熷熀鍩哄洟涓嶞/span>NPC鍙嶅簲褰㈡垚纰抽吀閰?/span> |
PEG-Silane |
纭呯兎鐗瑰埆閫傚悎涓庣緹鍩哄寲鐨勮〃闈㈠弽搴擖/span> |
PEG-Epoxide |
PEG-Epoxide涓庣緹鍩哄熀鍥㈠弽搴旂殑鏈€濂芥潯浠舵槸pH 8.5-9.5. |
浜斻€佸彔姘寲鐗╃殑PEG淇グ
PEG-Azide
PEG-Alkyne |
鍙犳爱鍖栫墿涓庣倲鍦ㄩ摐鍌寲鍓傚瓨鍦ㄤ笅鐢熸垚绋冲畾鐨凕/span>1,2,3-涓夋爱鍞戠幆銆傜О涓裹/span>Huisgen鍙犳爱鍖栫墿-鐐旂幆鍚堝姞鎴忺/span> |
鍏€佽〃闈↑/strong>PEG淇グ
PEG-Thiol |
PEG-Thiol鍙互鍜屽ぇ澶氭暟璐甸噾灞炶〃闈㈠弽搴旓紝渚嬪閲戙€侀摱绛堻/span> |
PEG-Silane |
PEG-Silane鍙互鍜岀緹鍩哄寲琛ㄩ潰鍙嶅簲锛岀鑳躲€佺幓鐠冦€佺緹鍩哄寲鎴栭吀婵€娲荤殑璐甸噾灞炶〃闈紝渚嬪閾傘€侀挴绛堻/span> |
涓冦€佽仛鍚堝弽搴旂殑PEG淇グ:鍦ㄨ嚜鐢卞熀寮曞彂鍓傘€佺传澶栫収灏勬垨楂樻俯涓嬶紝PEG浜よ仈鍓傝兘鑱氬悎褰㈡垚鍑濊兌銆佸井绮掓垨浜よ仈缃戠姸缁撴瀯锛岀敤浜庤嵂鐗╅噴鏀惧拰缁勭粐宸ョ▼
PEG-Thiol |
澶氳噦PEG-thiols鑳借嚜浜よ仈褰㈡垚浜岀～閿?/span>,鍦ㄩ€傚綋鐨勮繕鍘熸潯浠朵笅鍙互閫嗗悜鍙嶅簲 |
PEG-Acrylate |
鍙岃噦鎴栧洓鑷侟/span>PEG-涓欑儻閰搁叝, PEG-鐢插熀涓欑儻閰搁叝鎴朁/span>PEG-涓欑儻閰拌兒鑳戒氦鑱斿舰鎴愮ǔ瀹欬/span>C-C閿?/span> |
鍏€佸彲閫嗙殑PEG淇グ:浣跨敤鐗瑰畾鐨凱EG璇曞墏鍙戠敓鍙€嗙殑PEG淇グ锛屽彲浠ヨ瑙ｉ敭
PEG-Hydrazide |
PEG-閰拌偧鍙笌缇板熀(閰垨閱汓/span>)鍙嶅簲鐢熸垚閰拌厵锛屽湪閰告€ф潯浠朵笅瀹规槗姘磋В |
PEG-Thiol |
PEG-S-S-PEG浜岀～閿彲浠ュ湪閫傚綋鐨勮繕鍘熷墏瑁傝В |
鍏嶈矗澹版槑:涓婅堪淇℃伅浠呬緵閫夋嫨PEG淇グ璇曞墏鐨勫父瑙勬寚瀵笺€傚叿浣揚EG淇グ鎺ユ灊杩囩▼锛岃鍙傝€冩枃鐚垔鐗╁苟渚濋潬鑷繁鐨勫垽鏂€侟/em>
鍦ㄧ嚎鐣欒█
