基本信息
| 分子式 | C10H12ClNO2 |
| 分子量 | 213.66 |
| MDL编码 | MFCD01321057 |
| 存储条件 | Freezer -20℃ |
半岛bd体育手机客户端 描述
(R)-baclofen是一种γ-氨基丁酸衍生物，主要用于治疗痉挛。
靶点（IC50 & Targe）
GABAR
体外研究
Baclofen is a skeletal muscle relaxant used in the treatment of spasticity of spinal and cerebral origin. Although it is marketed as a racemic mixture, only the baclofen R-enantiomer is stereospecifically active at so called GAGAB-receptors. Researchers believe that the enantiomers of baclofen have different properties. It is claimed that the R-(?)-enantiomer is about 100 times more active than the S-(+)-enantiomer.
参考文献
[1] Falch E, et al. J Neurochem, 1986, 47(3), 898-903.
[2] Penn RD, et al. Lancet, 1984, 1(8385), 1078.
安全信息
| 图形或危害标志 |   |
| 提示语 | Warning |
| 危险说明 | H302 H410 |
| 防范说明 | P264 P270 P273 P301+P312 P330 P391 P501 |
| UN号码 | 3077 |
| 危险分类 | 9 |
| 包装等级 | III |
| WGK | 3 |
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