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Purvalanol B

品牌
J&K
CAS
212844-54-7
货号
100441
规格纯度
97%, 是CDK抑制剂
价格
523 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
- +
半岛bd体育手机客户端 名称:
212844-54-7
Purvalanol B
NG 95
半岛bd体育手机客户端 介绍:

基本信息

分子式 C20H25ClN6O3
分子量 432.90
MDL编码 MFCD04118312
存储条件 Freezer -20℃

半岛bd体育手机客户端 描述

Purvalanol B(NG-95) is a cyclin-dependent kinase inhibitor with IC50 values of 6, 6, 9, > 10,000, and 6 nM for cdc2/cyclin B, cdk2/cyclin A, cdk2/cyclin E, cdk4/cyclin D1 and cdk5-p35 respectively. IC50 Value: 6 nM(cdc2/cyclin B); 6 nM(cdk2/cyclin A); 9 nM(cdk2/cyclin E); 6 nM(cdk5-p35)[1] Target: cdc2/cyclin B; cdk2/cyclin E; cdk5-p35 in vitro: In vitro inhibitory activity against Cyclin-dependent kinase 1-cyclin B complex from starfish oocytes is 6 nM (IC50) [1]. In addition to CDK1, p42/p44 MAPK were found to be two major purvalanol-interacting proteins in five different mammalian cell lines (CCL39, PC12, HBL100, MCF-7 and Jurkat cells), suggesting the generality of the purvalanol/p42/p44 MAPK interaction. When cells were treated with purvalanol, p42/p44 MAPK and CDK1 activities were inhibited in a dose-dependent manner. Furthermore, purvalanol inhibited the nuclear accumulation of p42/p44 MAPK, an event dependent on the catalytic activity of these kinases [2]. in vivo:

靶点(IC50 & Targe)

Cdk2/cyclin A,6 nM

Cdk2/cyclin E,9 nM

Cdk5/p35,6 nM

Cdk2/cyclin B,6 nM

参考文献

[1]. purvalanol B (CID 448991) - Compound BioActivity Data

[2]. Knockaert M, et al. p42/p44 MAPKs are intracellular targets of the CDK inhibitor purvalanol. Oncogene. 2002 Sep 19;21(42):6413-24.

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