闈舵爣锛欬p style="text-indent: 2em;">MARCHF4

浜у搧鍒悕锛欬p style="text-indent: 2em;">MARCH-IV锛 MARCH4锛 RNF174锛 MARCHF4锛 membrane associated ring-CH-type finger 4锛 membrane associated ring-CH-type finger 4锛 E3 ubiquitin-protein ligase MARCHF4锛 E3 ubiquitin-protein ligase MARCH4锛 RING finger protein 174锛 RING-type E3 ubiquitin transferase MARCH4锛 RING-type E3 ubiquitin transferase MARCHF4锛 membrane associated ring finger 4锛 membrane-associated RING finger protein 4锛 membrane-associated RING-CH protein IV锛 membrane-associated ring finger (C3HC4) 4, E3 ubiquitin protein ligase锛 鑶滅浉鍏崇幆鎸囪泲鐧?锛

鑳屾櫙淇℃伅锛欬div style="text-indent: 2em;">MARCH4 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH4 reduces surface accumulation of several membrane glycoproteins by directing them to the endosomal compartment (Bartee et al., 2004 [PubMed 14722266]).[supplied by OMIM, Apr 2010],