闈舵爣锛欬p style="text-indent: 2em;">WDR35

浜у搧鍒悕锛欬p style="text-indent: 2em;">CED2锛 FAP118锛 IFT121锛 IFTA1锛 SRTD7锛 WDR35锛 WD repeat domain 35锛 WD repeat domain 35锛 WD repeat-containing protein 35锛 intraflagellar transport protein 121 homolog锛 naofen锛 WDR35铔嬬櫧锛

鑳屾櫙淇℃伅锛欬div style="text-indent: 2em;">This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. Two patients with Sensenbrenner syndrome / cranioectodermal dysplasia (CED) were identified with mutations in this gene, consistent with a possible ciliary function.