靶标９�p style="text-indent: 2em;">HCP5

产品别名９�p style="text-indent: 2em;">6S2650E� D6S2650E� P5-1� HCP5� HLA complex P5� HLA complex P5� HLA class I histocompatibility antigen protein P5� HLA complex P5 (non-protein coding)� HLA complex protein P5� MHC class I region ORF� 血红素转运蛋白5�

背景信息９�div style="text-indent: 2em;">HCP5 is a region present on chromosome 6p21.3 that is characterized by multiple duplicated gene families. HCP5 (HLA class I histocompatibility antigen protein P5), also known as P5-1, is a 132 amino acid protein that is encoded by a gene mapping to human chromosome 6p21.33. Localizing within the MHC class I region, HCP5 is not structurally related to other MHC class I genes, but does have high sequence similarity with HERV-L and HERV-16. HCP5 also has high sequence homology to retroviral Pol genes, making it a possible candidate for interaction with HIV-1 through an antisense mechanism that prevents retrovirus transcription. Single-nucleotide polymorphisms (SNPs) to the region of the HCP5 gene that corresponds with HLA-B has been linked to a lower HIV-1 viral set point. HCP5 is highly expressed in lymphoid tissues, spleen and activated lymphocytes, as well as B-cell and natural killer (NK) cell lines.