闈舵爣锛欬p style="text-indent: 2em;">TAF4

浜у搧鍒悕锛欬p style="text-indent: 2em;">TAF(II)130锛 TAF(II)135锛 TAF2C锛 TAF2C1锛 TAF4A锛 TAFII-130锛 TAFII-135锛 TAFII130锛 TAFII135锛 TAF4锛 TATA-box binding protein associated factor 4锛 TATA-box binding protein associated factor 4锛 transcription initiation factor TFIID subunit 4锛 RNA polymerase II TBP-associated factor subunit C锛 TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa锛 TAF4A RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135 kD锛 TATA box binding protein (TBP)-associated factor, RNA polymerase II, C1, 130kD锛 TBP-associated factor 4锛 transcription initiation factor TFIID 130 kDa subunit锛 transcription initiation factor TFIID 135 kD subunit锛 transcription initiation factor TFIID 135 kDa subunit锛

鑳屾櫙淇℃伅锛欬div style="text-indent: 2em;">Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the larger subunits of TFIID that has been shown to potentiate transcriptional activation by retinoic acid, thyroid hormone and