闈舵爣锛欬p style="text-indent: 2em;">MLLT1

浜у搧鍒悕锛欬p style="text-indent: 2em;">ENL锛 LTG19锛 YEATS1锛 MLLT1锛 MLLT1 super elongation complex subunit锛 MLLT1 super elongation complex subunit锛 protein ENL锛 CTC-503J8.6锛 ENL/MLL fusion锛 MLL/ENL fusion protein锛 MLLT1/MLL fusion锛 YEATS domain-containing protein 1锛 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog); translocated to, 1锛 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1锛 myeloid/lymphoid or mixed-lineage leukemia; translocated to, 1锛

鑳屾櫙淇℃伅锛欬div style="text-indent: 2em;">瓒呭欢闀垮鍚堜綋 (SEC) 鍦ㄨ皟鑺 RNA 鑱氬悎閰 II (RNAPII) 杞綍寤堕暱涓彂鎸ュ叧閿綔鐢 (1)銆係EC 鐢 AFF4銆丄FF1/AF4銆丮LLT3/AF9 鍜 MLLT1/ENL 铔嬬櫧缁勬垚銆傛贩鍚堢粏鑳炵郴鐧借鐥呯殑鍙戠梾鏈虹悊锛屽父涓庤繛鎺ヨ嚦缁勮泲鐧 H3 Lys4 鐢插熀杞Щ閰舵贩鍚堢粏鑳炵郴鐧借鐥 (MLL) 鍩哄洜鐨 SEC 浜氬熀杞綅鏈夊叧 (1-4)銆傚凡鍙戠幇 SEC 鍖呭惈 RNAPII 寤朵几鍥犲瓙 11-19 璧栨皑閰稿瘜闆嗙櫧琛€鐥 (ELL)銆丒LL2 鍜 ELL3锛屼互鍙婅兘澶熷鍔 RNAPII 浣撳杞綍鍌寲鐜囩殑鐩稿叧鍥犲瓙 EAF1 鍜 EAF2 (1,2,5-7)銆係EC 姝ｈ浆褰曞欢闀垮洜瀛 b (P-TEFb) 浣 RNAP II 鐨勬渶澶т簹鍩哄唴鐨勭晶鍩烘湯绔粨鏋勫煙鍦ㄤ竷鑲介噸澶嶇殑 Ser2 浣嶇偣纾烽吀鍖栥€係EC 璐熻浆褰曞欢闀垮洜瀛愩€丏RB 璇卞彂鍒烘縺鍥犲瓙 (DSIF) 鍜岃礋寤堕暱鍥犲瓙 (NELF)锛屽湪浠庤浆褰曡捣濮嬪拰鏆傚仠鑷崇敓浜ф€ц浆褰曞欢浼搁兘鍙戝嚭淇″彿杩涜杞崲 (2,8-10)銆傚甫鏈 SEC 鎴愬憳鐨 MLL 鐨勬煋鑹蹭綋鏄撲綅锛岄€犳垚 SEC 鍕熼泦鑷 MLL 璋冭妭鍩哄洜锛屼緥濡傞珮搴﹀彂鑲茶皟鑺傜殑 Hox 鍩哄洜锛屾剰鍛崇潃杩欎簺鍩哄洜鐨勮璋冭妭鍜岃繃琛ㄨ揪鍙兘淇冭繘鐧借鐥呭舰鎴 (1,2,9,11)銆傛槗浣嶈嚦 1/11-19-鐧借鐥呯殑 MLL (MLLT1/ENL) 涔熻鍙戠幇鏄绮掓矇榛樻牱 (Dot1L) 澶嶅悎浣撶殑缁勮泲鐧 H3 Lys79 鐢插熀杞Щ閰跺共鎵扮墿鐨勪竴閮ㄥ垎锛岃澶嶅悎浣撹鍙戠幇鍦ㄨ浆褰曞欢浼镐腑鍙戞尌浣滅敤銆傝澶嶅悎浣撹兘澶熻皟鑺傚熀鍥犵殑琛ㄨ揪锛屾瘮濡傛帶鍒跺彂鑲叉湡闂寸粏鑳炲娈栧拰鍒嗗寲鐨 Wnt 淇″彿杞閫氳矾闈舵爣鍩哄洜 (12,13)銆侟/div>

瀹夸富锛歊bt
绫诲瀷锛歅ab
鍚岀鍨婜IgG
搴旂敤锛歐B
绾寲鏂瑰紡锛氫翰鍜岀函鍖朁br/>鍋惰仈鐗╋細Unconjugated
鎬х姸锛氭恫浣
瀛樺偍婧舵恫锛氬弬闃呰鏄庝功
娴撳害锛欱atch dependent (Please refer to the vial label for the specific concentration.)
绋€閲婃瘮渚婜 Optimal dilutions/concentrations should be determined by the end user
鍌ㄥ瓨锛氱粡甯镐娇鐢ㄥ垯4掳C淇濆瓨銆?20掳C淇濆瓨涓嶈秴杩囦袱骞淬€傞伩鍏嶅弽澶嶅喕铻嶃€侟br/>娉ㄦ剰浜嬮」锛氫粎渚涘疄楠屽浣跨敤銆備笉閫傜敤浜庝汉绫绘垨鍔ㄧ墿鐨勪换浣曚复搴婏紝娌荤枟鎴栬瘖鏂敤閫斻€備笉閫傚悎鍔ㄧ墿鎴栦汉绫婚鐢ㄣ€侟/p>