靶标９�p style="text-indent: 2em;">GALNT1

产品别名９�p style="text-indent: 2em;">GALNAC-T1� GALNT1� polypeptide N-acetylgalactosaminyltransferase 1� polypeptide N-acetylgalactosaminyltransferase 1� polypeptide N-acetylgalactosaminyltransferase 1� GalNAc transferase 1� UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 1� UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 1 (GalNAc-T1)� polypeptide GalNAc transferase 1� pp-GaNTase 1� protein-UDP acetylgalactosaminyltransferase 1� 多肽N-乙酰氨基半乳糖转移酶1�

背景信息９�div style="text-indent: 2em;">The UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase (GalNAc-T) family of enzymes are substrate-specific proteins that catalyze the transfer of GalNAc (N-acetylgalactosamine) to serine and threonine residues onto various proteins, thereby initiating mucin-type O-linked glycosylation in the Golgi apparatus. GalNAc-T1, also known as GALNT1 (Polypeptide N-acetylgalactosaminyltransferase 1), is a ubiquitously expressed 559 amino acid single-pass type II membrane protein that localizes to the Golgi apparatus and, like other GalNAc-Ts, contains a stem region and a C-terminal ricin lectin-like domain. GalNAc-T1 catalyzes the first reaction in O-linked oligosaccharide biosynthesis, namely the transfer of an N-acetyl-D-galactosamine residue to a protein acceptor. GalNAc-T1 uses calcium and manganese as cofactors. Due to alternative splicing events, two GalNAc-T1 isoforms are expressed.