闈舵爣锛欬p style="text-indent: 2em;">BPTF

浜у搧鍒悕锛欬p style="text-indent: 2em;">FAC1锛 FALZ锛 NEDDFL锛 NURF301锛 BPTF锛 bromodomain PHD finger transcription factor锛 bromodomain PHD finger transcription factor锛 nucleosome-remodeling factor subunit BPTF锛 bromodomain and PHD domain transcription factor锛 bromodomain and PHD finger-containing transcription factor锛 fetal Alz-50 clone 1 protein锛 fetal Alz-50 reactive clone 1锛 fetal Alzheimer antigen锛 nucleosome remodeling factor, large subunit锛 鑳庡効闃垮吂娴烽粯鐥呮姉鍘?鏍稿皬浣撻噸濉戝洜瀛愶紱

鑳屾櫙淇℃伅锛欬div style="text-indent: 2em;">This gene was identified by the reactivity of its encoded protein to a monoclonal antibody prepared against brain homogenates from patients with Alzheimer's disease. Analysis of the original protein (fetal Alz-50 reactive clone 1, or FAC1), identified as an 810 aa protein containing a DNA-binding domain and a zinc finger motif, suggested it might play a role in the regulation of transcription. High levels of FAC1 were detected in fetal brain and in patients with neurodegenerative diseases. The protein encoded by this gene is actually much larger than originally thought, and it also contains a C-terminal bromodomain characteristic of proteins that regulate transcription during proliferation. The encoded protein is highly similar to the largest subunit of the Drosophila NURF (nucleosome remodeling factor) complex. In Drosophila, the NURF complex, which catalyzes nucleosome