靶标９�p style="text-indent: 2em;">DPH1

产品别名９�p style="text-indent: 2em;">DEDSSH� DPH2L� DPH2L1� OVCA1� DPH1� diphthamide biosynthesis 1� diphthamide biosynthesis 1� 2-(3-amino-3-carboxypropyl)histidine synthase subunit 1� DPH-like 1� DPH1 homolog� DPH2-like 1� S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase 1� candidate tumor suppressor in ovarian cancer 1� diphthamide biosynthesis protein 1� diphthamide biosynthesis protein 2 homolog-like 1� diphtheria toxin resistance protein 1� diptheria toxin resistance protein required for diphthamide biosynthesis (Saccharomyces)-like 1� ovarian cancer-associated gene 1 protein� ovarian tumor suppressor candidate 1� 卵巢癌相关基�?�

背景信息９�div style="text-indent: 2em;">OVCA1 is required for the first step in the synthesis of diphthamide, a unique posttranslationally modified histidine found only in translation elongation factor-2 (EEF2; MIM 130610). This modification is conserved from archaebacteria to humans and serves as the target for ADP-ribosylation and inactivation of EEF2 by diphtheria toxin (DT) and Pseudomonas exotoxin A. OVCA1 is one of several enzymes involved in synthesis of diphthamide in EEF2.