闈舵爣锛欬p style="text-indent: 2em;">DMWD

浜у搧鍒悕锛欬p style="text-indent: 2em;">D19S593E锛 DMR-N9锛 DMRN9锛 gene59锛 DMWD锛 DM1 locus, WD repeat containing锛 DM1 locus, WD repeat containing锛 dystrophia myotonica WD repeat-containing protein锛 dystrophia myotonica, WD repeat containing锛 dystrophia myotonica-containing WD repeat motif protein锛 protein 59锛 寮虹洿鎬ц倢钀ュ吇涓嶈壇鐩稿叧铔嬬櫧9锛

鑳屾櫙淇℃伅锛欬div style="text-indent: 2em;">DMWD is a 674 amino acid protein containing five WD repeats. DMWD may play a role in the development of mental symptoms in severe cases of myotonic dystrophy, a chronic multisystemic disease characterized by wasting of the muscles, heart conduction defects, cataracts, endocrine changes and myotonia. The DMWD gene is located upstream of the DMPK gene and is prominently expressed in tissues affected in myotonic dystrophy patients. DMWD may also contribute to regulation in meiosis. DMWD is expressed in kidney and spleen, with strongest expression in brain, liver and testis. The gene encoding DMWD maps to human chromosome 19q13.32 and mouse chromosome 7 A3.