闈舵爣锛欬p style="text-indent: 2em;">ATP2B1

浜у搧鍒悕锛欬p style="text-indent: 2em;">MRD66锛 PMCA1锛 PMCA1kb锛 ATP2B1锛 ATPase plasma membrane Ca2+ transporting 1锛 ATPase plasma membrane Ca2+ transporting 1锛 plasma membrane calcium-transporting ATPase 1锛 ATPase, Ca++ transporting, plasma membrane 1锛 plasma membrane calcium pump锛 ATP閰堕挋绂诲瓙杞繍铔嬬櫧PMCA3锛 缁嗚優鑶滈挋ATP閰?锛

鑳屾櫙淇℃伅锛欬div style="text-indent: 2em;">The protein encoded by this gene belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased by alternative splicing of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues. This gene encodes the plasma membrane calcium ATPase isoform 1. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]