应用
1-Methylpiperazine is used in the preparation of 2-(4-methyl-1-piperazinylmethyl)acrylophenone. It is involved in the preparation of 1-(4-methoxy-phenyl)-4-methyl-piperazine by reacting with 1-chloro-4-methoxy-benzene. It acts as an intermediate in the synthesis of active pharmaceutical ingredients like ofloxacin, rifampicin, clozapine, sildenafil, trifluoperazine and zopiclone. Further, it is used as a mimic template in the preparation of molecularly imprinted microspheres. In addition to this, it is used in the generation of difunctional strong anion-exchange stationary phase from a 1,4-diazacyclohexane derivative.

备注
Hygroscopic. Moisture sensitive. Incompatible with acids, acid chlorides, acid anhydrides, strong oxidizing agents and carbon dioxide.

基本信息

MDL
MFCD00005966

EINECS
203-639-5

分子式
C₅H₁₂N₂

分子量
100.17

熔点
-6°

沸点
137-139°

闪点
34°(93°F)

密度
0.903

折射率
1.4655

灵敏度
Air Sensitive. Store under Argon. Ambient temperatures.

形态
Liquid

溶解性
Miscible with water and methanol.

Beilstein
102724

GHS危害和防范说明

GHS符号

Hazard Statements
H226-H302-H312-H331-H314-H318
Flammable liquid and vapour.Harmful if swallowed.Harmful in contact with skin.Toxic if inhaled.Causes severe skin burns and eye damage.Causes serious eye damage.

Precautionary Statements
P210-P260h-P303+P361+P353-P305+P351+P338-P405-P501a
Keep away from heat/sparks/open flames/hot surfaces. - No smoking.Keep away from heat/sparks/open flames/hot surfaces. - No smoking.IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.Store locked up.Dispose of contents/container in accordance with local/regional/national/international regulations.

安全信息

危险等级
8

包装组
II

危险类别
10-21/22-34
Flammable.Harmful in contact with skin and if swallowed.Causes burns.

安全等级
20-23-26-36/37/39-45-60
When using do not eat or drink.Do not breathe gas/fumes/vapour/spray (appropriate wording to be specified by the manufacturer).In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.Wear suitable protective clothing, gloves and eye/face protection.In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).This material and its container must be disposed of as hazardous waste

欧盟危险品标志

RTECS
TM1225000

TSCA
是