应用
15-Crown-5 is used as an efficient phase transfer catalyst and as a complexing agent. It is used to isolate oxonium ion (H₇O₃)⁺salts especially from a solution of tetrchloroauric acid. It catalyzes the O-alkylation of the sodium salts of carboxylic acids in the penicillin and cephalosporin series, thereby facilitating esterification reaction without usage of acid. It is also used to facilitate the Williamson synthesis of ethers with hindered alcohols and sodium hydride. It is used with lithium aluminum hydride, for performing reduction reactions in hydrocarbon solvents. Further, it is involved in the Horner-Wadsworth-Emmons reaction to prepare stilbenes from aldehydes.

备注
Hygroscopic. Moisture sensitive. Incompatible with strong oxidizing agents and strong acids.

基本信息

MDL
MFCD00005110

EINECS
251-379-6

分子式
C₁₀H₂₀O₅

分子量
220.27

沸点
150-155°/0.5mm

闪点
>110°(230°F)

密度
1.110

折射率
1.4650

灵敏度
Hygroscopic. Ambient temperatures.

形态
Liquid

溶解性
Miscible with organic solvents.

Beilstein
1618144

GHS危害和防范说明

GHS符号

Hazard Statements
H302-H313-H315-H319-H335
Harmful if swallowed.May be harmful in contact with skin.Causes skin irritation.Causes serious eye irritation.May cause respiratory irritation.

Precautionary Statements
P261-P280a-P305+P351+P338-P304+P340-P405-P501a
Avoid breathing dust/fume/gas/mist/vapours/spray.Wear protective gloves and eye/face protection.IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing.Store locked up.Dispose of contents/container in accordance with local/regional/national/international regulations.

安全信息

危险类别
22-36/37/38
Harmful if swallowed.Irritating to eyes, respiratory system and skin.

安全等级
23-26-36/37
Do not breathe gas/fumes/vapour/spray (appropriate wording to be specified by the manufacturer).In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.Wear suitable protective clothing and gloves.

欧盟危险品标志

RTECS
SB0200000

TSCA
是