应用
1H-Benzotriazol-1-yloxytris(dimethylamino)phosphonium hexafluorophosphate is used as a reagent for peptide coupling, lactonization, selective esterification, amidation of alfa amino acids without racemization and synthesis of magnolamide for antioxidative activity and catalyst for 9-acridinecaroboxamide derivative. It is also used as a precursor for the synthesis of phenyl esters of amino acids. It acts as a substitute for (Benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate (BOP) reagent.

备注
Moisture and light sensitive. Incompatible with strong oxidizing agents. Store in a cool place. Keep the container tightly closed.

基本信息

MDL
MFCD00011948

EINECS
260-279-1

分子式
C₁₂H₂₂F₆N₆OP₂

分子量
442.29

熔点
ca 138° dec.

灵敏度
Keep Cold. Moisture Sensitive. Light Sensitive. Store under Nitrogen.

形态
Crystalline powder

溶解性
Soluble in methanol, acetone and dichloromethane. Insoluble in water.

Beilstein
4287025

GHS危害和防范说明

GHS符号

Hazard Statements
H228-H315-H319-H335
Flammable solid.Causes skin irritation.Causes serious eye irritation.May cause respiratory irritation.

Precautionary Statements
P210-P261-P280-P305+P351+P338-P405-P501a
Keep away from heat/sparks/open flames/hot surfaces. - No smoking.Avoid breathing dust/fume/gas/mist/vapours/spray.Wear protective gloves/protective clothing/eye protection/face protection.IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.Store locked up.Dispose of contents/container in accordance with local/regional/national/international regulations.

安全信息

危险等级
4.1

包装组
II

危险类别
11-36/37/38-44
Highly flammable.Irritating to eyes, respiratory system and skin.Risk of explosion if heated under confinement.

安全等级
26-37-60
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.This material and its container must be disposed of as hazardous waste

欧盟危险品标志

TSCA
否